H-HYP-OET HCL

Base Information

• Chemical Name: H-HYP-OET HCL
• CAS No.: 33996-30-4
• Molecular Formula: C7H13NO3.ClH
• Molecular Weight: 195.646
• Hs Code.: 2933990090
• Mol file: 33996-30-4.mol

Synonyms:L-Proline,4-hydroxy-, ethyl ester, hydrochloride, (4R)- (9CI);L-Proline, 4-hydroxy-,ethyl ester, hydrochloride, trans-;Proline, 4-hydroxy-, ethyl ester,hydrochloride, L- (6CI,8CI);(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acidethyl ester hydrochloride;4-Hydroxy-L-proline ethyl ester hydrochloride;Hydroxyprolineethyl ester hydrochloride;L-Hydroxyproline ethyl ester hydrochloride;

Chemical Property of H-HYP-OET HCL

Chemical Property:

• Vapor Pressure: 0.00014mmHg at 25°C
• Melting Point: 150-153℃
• Boiling Point: 297.2 °C at 760 mmHg
• Flash Point: 133.5 °C
• PSA: 58.56000
• LogP: 0.40310
• Storage Temp.: Store at 0-5°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-4-trans-Hydroxyproline ethyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: H-Hyp-OEt HCl

Technology Process of H-HYP-OET HCL

There total 2 articles about H-HYP-OET HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + 4R-4-hydroxyproline (51-35-4,30724-02-8) → trans-4-hydroxy-L-proline ethyl ester hydrochloride (33996-30-4)

Guidance literature:

With thionyl chloride; for 18h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2012.10.076

Reference yield:

→ trans-4-hydroxy-L-proline ethyl ester hydrochloride (33996-30-4)

Guidance literature:

Reference yield: 98.0%

trans-4-hydroxy-L-proline ethyl ester hydrochloride (33996-30-4) + benzyl chloroformate (501-53-1,94274-21-2) → N-CBz-trans-4-hydroxy-L-proline ethyl ester

Guidance literature:

With triethylamine; In methanol; at 0 - 20 ℃;

DOI:10.1021/np070673w

upstream raw materials:

ethanol

4R-4-hydroxyproline

Downstream raw materials:

(2S,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester

N-<4-Methyl-3-(benzyloxy)-2-nitrobenzoyl>hydroxyproline ethyl ester

N--N'-<(2,2,2-trichloroethoxy)carbonyl>-L-alanyl>-L-4-hydroxyproline ethyl ester

(2S,4R)-ethyl N¹-benzyl-4-hydroxypyrrolidine-2-carboxylate

Refernces

• 1、 Chauhan, ManMohan Singh,Singh, Surendra. "Asymmetric reduction of ketones catalyzed by α,α-diphenyl-(L)-prolinol modified with imidazolium ionic liquid and BH3·SMe2 as a recoverable catalyst". . p. 184 - 189. Retrieved 2015/02/19.
• 2、 Miyamura, Hiroyuki,Choo, Gerald C. Y.,Yasukawa, Tomohiro,Yoo, Woo-Jin,Kobayashi, Shu. "A heterogeneous layered bifunctional catalyst for the integration of aerobic oxidation and asymmetric C-C bond formation". supporting information. p. 9917 - 9919. Retrieved 2013/10/22.