METHYL 4-METHYL-1H-PYRROLE-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL 4-METHYL-1H-PYRROLE-2-CARBOXYLATE
• CAS No.: 34402-78-3
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 2933990090
• Mol file: 34402-78-3.mol

Synonyms:Pyrrole-2-carboxylicacid, 4-methyl-, methyl ester (7CI,8CI);4-Methyl-1H-pyrrole-2-carboxylic acidmethyl ester;Methyl 4-methylpyrrole-2-carboxylate;

Chemical Property of METHYL 4-METHYL-1H-PYRROLE-2-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0.022mmHg at 25°C
• Melting Point: 73-74℃ (cyclohexane )
• Refractive Index: 1.524
• Boiling Point: 250.2°Cat760mmHg
• PKA: 15.46±0.50(Predicted)
• Flash Point: 105.1°C
• PSA: 42.09000
• Density: 1.141g/cm³
• LogP: 1.10970
• Storage Temp.: -20°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl4-Methylpyrrole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-Methylpyrrole-2-carboxylate is a useful reagent for preparation of (E)-3-(2-(N-phenylcarbamoyl)vinyl)pyrrole-2-carboxylic acid derivatives, a novel class of glycine site antagonists.

Technology Process of METHYL 4-METHYL-1H-PYRROLE-2-CARBOXYLATE

There total 24 articles about METHYL 4-METHYL-1H-PYRROLE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methyl (2S)-4-methylene-1-p-toluenesulfonylpyrroplidine-2-carboxylate (1173715-82-6) → methyl 4-methyl-1H-pyrrole-2-carboxylate (34402-78-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; for 12h; Reflux;

DOI:10.1248/cpb.57.167

Reference yield: 94.0%

1-Benzenesulfonyl-4-methyl-1H-pyrrole-2-carboxylic acid methyl ester (175235-82-2) → methyl 4-methyl-1H-pyrrole-2-carboxylate (34402-78-3)

Guidance literature:

With lithium; In methanol; Heating;

DOI:10.1016/0040-4039(96)00098-6

Reference yield: 83.0%

1-Benzoyl-4-methyl-1H-pyrrole-2-carboxylic acid methyl ester (129339-72-6) → benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) + methyl 4-methyl-1H-pyrrole-2-carboxylate (34402-78-3)

Guidance literature:

With sodium methylate; In methanol;

upstream raw materials:

diazomethane

4-methyl-1H-pyrrole-2-carboxylic acid

2-nitropropyl acetate

isocyanoacetic acid methyl ester

Downstream raw materials:

C₁₃H₁₀N₂O₅S

C₁₉H₂₁N₃O₆S

C₁₉H₂₁N₃O₆S

5-Isopropyl-4-methyl-3-((E)-2-phenylcarbamoyl-vinyl)-1H-pyrrole-2-carboxylic acid methyl ester

Refernces

• 1、 Wright, Mathew T.,Carroll, David G.,Smith, Timothy M.,Smith, Stanton Q.. "Synthesis of alkylpyrroles by use of a vinamidinium salt". experimental part. p. 4150 - 4152. Retrieved 2010/08/19.
• 2、 Tehrani, Kourosch Abbaspour,Borremans, Didier,De Kimpe, Norbert. "Synthesis of 2-acyl-3-chloropyrroles: Application to the synthesis of the trail pheromone of the ant Atta texana". . p. 4133 - 4152. Retrieved 2007/10/03.