Propanoic acid, 3-[5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[[(2S)-2-(hydroxymethyl)-1- pyrrolidinyl]carbonyl]-2-methoxyphenoxy]-, phenylmethyl ester

Base Information

Chemical Name:Propanoic acid, 3-[5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[[(2S)-2-(hydroxymethyl)-1- pyrrolidinyl]carbonyl]-2-methoxyphenoxy]-, phenylmethyl ester
CAS No.:679005-39-1
Molecular Formula:C28H36N2O8
Molecular Weight:528.602
Hs Code.:

Propanoic acid,
3-[5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[[(2S)-2-(hydroxymethyl)-1-
pyrrolidinyl]carbonyl]-2-methoxyphenoxy]-, phenylmethyl ester

Synonyms:

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Chemical Property of Propanoic acid, 3-[5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[[(2S)-2-(hydroxymethyl)-1- pyrrolidinyl]carbonyl]-2-methoxyphenoxy]-, phenylmethyl ester

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Technology Process of Propanoic acid, 3-[5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[[(2S)-2-(hydroxymethyl)-1- pyrrolidinyl]carbonyl]-2-methoxyphenoxy]-, phenylmethyl ester

There total 9 articles about Propanoic acid, 3-[5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-[[(2S)-2-(hydroxymethyl)-1- pyrrolidinyl]carbonyl]-2-methoxyphenoxy]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 679005-38-0
3-[5-amino-4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxyphenoxy]propionic acid benzyl ester

: 679005-39-1
3-[5-tert-butoxycarbonylamino-4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxyphenoxy]propionic acid benzyl ester

Guidance literature:: In tetrahydrofuran; for 18h; Heating;
DOI:10.1016/j.bmcl.2003.12.017 DOI:10.1021/jm051199z

Reference yield:

: 679005-36-8
4-(2-benzyloxycarbonylethoxy)-5-methoxy-2-nitrobenzoic acid

: 679005-39-1
3-[5-tert-butoxycarbonylamino-4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxyphenoxy]propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: (COCl)2; DMF / CH₂Cl₂ / 18 h / 20 °C

2: 100 percent / Et₃N / CH₂Cl₂ / -30 - 20 °C

3: SnCl₂*2H₂O / methanol / 6 h / Heating

4: tetrahydrofuran / 18 h / Heating

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm051199z

Reference yield:

: 219562-36-4
3-(4-carboxy-2-methoxy-5-nitrophenoxy)propanoic acid

: 679005-39-1
3-[5-tert-butoxycarbonylamino-4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxyphenoxy]propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 56 percent / 4-toluenesulfonic acid / toluene / 3.5 h / Heating

2: (COCl)2; DMF / CH₂Cl₂ / 18 h / 20 °C

3: 100 percent / Et₃N / CH₂Cl₂ / -30 - 20 °C

4: SnCl₂*2H₂O / methanol / 6 h / Heating

5: tetrahydrofuran / 18 h / Heating

With oxalyl dichloride; toluene-4-sulfonic acid; triethylamine; N,N-dimethyl-formamide; tin(ll) chloride; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm051199z