Thiazole, 2-(4-methoxyphenyl)-5-phenyl-

Base Information

• Chemical Name: Thiazole, 2-(4-methoxyphenyl)-5-phenyl-
• CAS No.: 68004-02-4
• Molecular Formula: C16H13NOS
• Molecular Weight: 267.351
• Mol file: 68004-02-4.mol

Synonyms:

Chemical Property of Thiazole, 2-(4-methoxyphenyl)-5-phenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiazole, 2-(4-methoxyphenyl)-5-phenyl-

There total 16 articles about Thiazole, 2-(4-methoxyphenyl)-5-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C16H13NO2S (1016990-17-2) → 2-(4-methoxyphenyl)-5-phenyl-1,3-thiazole (68004-02-4)

Guidance literature:

With water; ammonium chloride; zinc; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

Reference yield: 91.0%

1-(methylsulfonyl)-4-phenyl-1H-1,2,3-triazole (1135539-10-4) + O-methyl 4-methoxybezenecarbothioate (5925-50-8) → 2-(4-methoxyphenyl)-5-phenyl-1,3-thiazole (68004-02-4)

Guidance literature:

1-(methylsulfonyl)-4-phenyl-1H-1,2,3-triazole; O-methyl 4-methoxybezenecarbothioate; With C₁₉H₃₄O₈Rh₂; In chloroform; at 70 ℃; for 1h; Inert atmosphere; Glovebox; Molecular sieve; Sealed tube;

In chloroform; at 20 ℃; for 1h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/acs.orglett.5b00960

Reference yield: 88.0%

5-phenylthiazole (1826-13-7) + para-iodoanisole (696-62-8) → 2-(4-methoxyphenyl)-5-phenyl-1,3-thiazole (68004-02-4)

Guidance literature:

With bis(1,10-phenanthroline)palladium(II) hexafluorophosphate; caesium carbonate; In N,N-dimethyl acetamide; at 150 ℃; for 20h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo200067y

upstream raw materials:

4-methoxy-N-(2-oxo-2-phenylethyl)benzamide

2-(4-methoxyphenyl)-1,3-thiazole

iodobenzene

phenylboronic acid

Downstream raw materials:

2-(4-methoxyphenyl)-4-(4-trifluoromethylphenyl)-5-phenylthiazole

4-(4-methoxy-phenyl)-5-phenyl-thiazole

3-(4-methoxy-phenyl)-4-phenyl-isothiazole