2-(4-Methoxyphenyl)-1,3-thiazole

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-1,3-thiazole
• CAS No.: 27088-84-2
• Molecular Formula: C10H9NOS
• Molecular Weight: 191.254
• DSSTox Substance ID: DTXSID00461576
• Wikidata: Q82285949
• Mol file: 27088-84-2.mol

Synonyms:2-(4-methoxyphenyl)thiazole;27088-84-2;2-(4-methoxyphenyl)-1,3-thiazole;2-(4-Methoxy-phenyl)-thiazole;4-methoxyphenyl thiazole;SCHEMBL468161;DTXSID00461576;LRPLPGGILHNNFA-UHFFFAOYSA-N;AKOS015945297;AT38524;BS-25338;FT-0715143

Chemical Property of 2-(4-Methoxyphenyl)-1,3-thiazole

Chemical Property:

• Melting Point: 12-15 °C
• Boiling Point: 156-158 °C(Press: 6 Torr)
• PKA: 2.82±0.10(Predicted)
• PSA: 50.36000
• Density: 1.184±0.06 g/cm3(Predicted)
• LogP: 2.81870
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 191.04048508
• Heavy Atom Count: 13
• Complexity: 157

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Methoxyphenyl)-1,3-thiazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=NC=CS2

Technology Process of 2-(4-Methoxyphenyl)-1,3-thiazole

There total 22 articles about 2-(4-Methoxyphenyl)-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

p-methoxythiobenzamide (2362-64-3) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 2-(4-methoxyphenyl)-1,3-thiazole (27088-84-2)

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1021/jm00156a028

Reference yield: 90.0%

5-Hydroxymethyl-2-(4-methoxyphenyl)-thiazole (937668-37-6) → 2-(4-methoxyphenyl)-1,3-thiazole (27088-84-2)

Guidance literature:

With potassium tert-butylate; oxygen; In toluene; at 80 ℃; for 14h;

DOI:10.1021/acs.orglett.9b00563

Reference yield: 88.0%

2-bromo-1,3-thiazole (3034-53-5,215777-74-5) + 4-methoxyphenylboronic acid (5720-07-0) → 2-(4-methoxyphenyl)-1,3-thiazole (27088-84-2)

Guidance literature:

With sodium carbonate; palladium diacetate; triphenylphosphine; In water; N,N-dimethyl-formamide; at 100 ℃; for 3h;

upstream raw materials:

p-methoxythiobenzamide

Bromoacetaldehyde diethyl acetal

1,3-thiazole

para-iodoanisole

Downstream raw materials:

2-(4-hydroxyphenyl) thiazole

2-(4-methoxyphenyl)-5-phenyl-1,3-thiazole

5-bromo-2-(4-methoxyphenyl)-1,3-thiazole

3,4-O-isopropylidene-1,6-di-O-(4-thiazol-2-yl-phenyl)-D-mannitol

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