Technology Process of Butanenitrile, 3-(phenylamino)-, (3S)-
There total 3 articles about Butanenitrile, 3-(phenylamino)-, (3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3S)-3-aminobutanenitrile; phenylboronic acid;
With
pyridine; copper diacetate;
oxygen;
In
DMF (N,N-dimethyl-formamide);
at 65 ℃;
for 18h;
for 18h;
- Guidance literature:
-
bromobenzene; (3S)-3-aminobutanenitrile;
With
caesium carbonate;
In
toluene;
for 0.75h;
Inert atmosphere;
With
phenylboronic acid;
palladium diacetate; DavePhos;
In
tetrahydrofuran; toluene;
for 0.75h;
Inert atmosphere;
In
tetrahydrofuran; toluene;
at 80 ℃;
- Guidance literature:
-
With
bis{(1R)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyl}cyclohexylphosphine; nickel(II) perchlorate hexahydrate;
at 20 ℃;
for 24h;
optical yield given as %ee;
Inert atmosphere;
DOI:10.1016/j.tetasy.2008.11.010