(R)-(+)-PIPERIDINE-2-ETHANOL

Base Information

• Chemical Name: (R)-(+)-PIPERIDINE-2-ETHANOL
• CAS No.: 68419-38-5
• Molecular Formula: C7H15NO
• Molecular Weight: 129.202
• Hs Code.: 2933399990
• Mol file: 68419-38-5.mol

Synonyms:(-) piperidine-2-ethanol;(R)-homopipecolic alcohol;(R)-2-(Piperidin-2-yl)ethanol;(2R)-2-Piperidineethanol;(R)-2-Piperidineethanol hydrochloride;(R)-2-(2-Hydroxyethyl)piperidine hydrochloride;(2R)-2-(2-methoxyethyl)piperidine;(R)-(+)-Piperidine-2-Ethanol;2-((2R)-piperidin-2-yl)ethanol;(R)-2-Piperidineethanol;

Chemical Property of (R)-(+)-PIPERIDINE-2-ETHANOL

Chemical Property:

• Appearance/Colour: white crystalline powder
• Boiling Point: 234.5°C at 760 mmHg
• PKA: 15.15±0.10(Predicted)
• Flash Point: 102.222°C
• PSA: 32.26000
• Density: 0.939g/cm3
• LogP: 0.83970
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-Piperidineethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-(+)-PIPERIDINE-2-ETHANOL is useful in preparation of a novel class of pyrazolopyrimidines as inhibitors of protein and checkpoint kinases. And it is useful in treatment and prophylaxis of HCV infection and other diseases such as cancer.

Technology Process of (R)-(+)-PIPERIDINE-2-ETHANOL

There total 10 articles about (R)-(+)-PIPERIDINE-2-ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

{(R)-1-[(R)-1-(2-Methoxy-phenyl)-ethyl]-6-oxo-piperidin-2-yl}-acetaldehyde (327158-15-6) → (2R)-2-(2-methoxyethyl)piperidine (68419-38-5)

Guidance literature:

{(R)-1-[(R)-1-(2-Methoxy-phenyl)-ethyl]-6-oxo-piperidin-2-yl}-acetaldehyde; With lithium aluminium tetrahydride; In diethyl ether; Heating;

With hydrogen; palladium on activated charcoal; In methanol; Further stages.;

DOI:10.1021/ol0003228

Reference yield: 17.0%

2(RS)-(2-hydroxyethyl)piperidine (1484-84-0) → (2R)-2-(2-methoxyethyl)piperidine (68419-38-5)

Guidance literature:

Resolution of racemate; Industrial scale;

Reference yield:

2(RS)-(2-hydroxyethyl)piperidine (1484-84-0) + C15H20O2 → (2R)-1-(3-mesitylpropanoyl)-2-(2-methoxyethyl)piperidine + (2S)-1-(3-Mesitylpropanoyl)-2-(2-methoxyethyl)piperidine + (2S)-2-(2-methoxyethyl)piperidine (103639-57-2) + (2R)-2-(2-methoxyethyl)piperidine (68419-38-5)

Guidance literature:

With 2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; potassium carbonate; In Isopropyl acetate; at 23 ℃; for 24h; Resolution of racemate;

DOI:10.1039/c2cc34907h

upstream raw materials:

{(R)-1-[(R)-1-(2-Methoxy-phenyl)-ethyl]-6-oxo-piperidin-2-yl}-acetaldehyde

2(RS)-(2-hydroxyethyl)piperidine

glutaric anhydride,

(9aS,10R)-10-Methyl-1,2,3,9a-tetrahydro-10H-9-oxa-4a-aza-anthracen-4-one

Downstream raw materials:

(R)-2-(piperidin-2'-yl)ethanoic acid

(2R)-1-[3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acryloyl]-2-(2-hydroxyethyl)piperidine

(R)-2-(1-(tert-butoxycarbonyl)piperidin-2-yl) acetic acid

(R)-2-methoxycarbonylmethylpiperidine-1-carboxylic acid tert-butyl ester