(S)-2-(Piperidin-2-yl)ethanol

Base Information

• Chemical Name: (S)-2-(Piperidin-2-yl)ethanol
• CAS No.: 103639-57-2
• Molecular Formula: C7H15NO
• Molecular Weight: 129.202
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID30353011
• Nikkaji Number: J2.447.213B
• Mol file: 103639-57-2.mol

Synonyms:(S)-2-(Piperidin-2-yl)ethanol;103639-57-2;(S)-2-Piperidineethanol;(S)-2-(2-HYDROXYETHYL)PIPERIDINE;2-[(2s)-piperidin-2-yl]ethanol;(S)-(-)-Piperidine-2-Ethanol;2-Piperidineethanol, (S)-;MFCD08461072;(S)-2-(piperidin-2-yl)ethan-1-ol;2-[(2S)-Piperidin-2-yl]ethan-1-ol;(S)-piperidine-2-ethanol;2-[(2S)-2-piperidyl]ethanol;SCHEMBL1010137;(S)-(-)piperidine-2-Ethanol;DTXSID30353011;PTHDBHDZSMGHKF-ZETCQYMHSA-N;AMY21751;BCP14610;AKOS006281675;CS-W019797;DS-13983;(S)-(-)-piperidine-2-ethanol, AldrichCPR;P10605;A896393;J-001015

Chemical Property of (S)-2-(Piperidin-2-yl)ethanol

Chemical Property:

• Melting Point: 60-62°C
• Boiling Point: 234.5±13.0 °C(Predicted)
• PKA: 15.15±0.10(Predicted)
• PSA: 32.26000
• Density: 0.939±0.06 g/cm3(Predicted)
• LogP: 0.83970
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 129.115364102
• Heavy Atom Count: 9
• Complexity: 75.3

Purity/Quality:

97% ^*data from raw suppliers

(S)-2-Piperidineethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)CCO
• Isomeric SMILES: C1CCN[C@@H](C1)CCO
• Uses: Useful in preparation of a novel class of pyrazolopyrimidines as inhibitors of protein and checkpoint kinases useful in treatment and prophylaxis of HCV infection and other diseases such as cancer. (S)-2-(2-Hydroxyethyl)piperidine is used in preparation of a novel class of pyrazolopyrimidines as inhibitors of protein and checkpoint kinases useful in treatment and prophylaxis of HCV infection and other diseases such as cancer.

Technology Process of (S)-2-(Piperidin-2-yl)ethanol

There total 7 articles about (S)-2-(Piperidin-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2(RS)-(2-hydroxyethyl)piperidine (1484-84-0) + C15H20O2 → (2R)-1-(3-mesitylpropanoyl)-2-(2-methoxyethyl)piperidine + (2S)-1-(3-Mesitylpropanoyl)-2-(2-methoxyethyl)piperidine + (2S)-2-(2-methoxyethyl)piperidine (103639-57-2) + (2R)-2-(2-methoxyethyl)piperidine (68419-38-5)

Guidance literature:

With 2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; potassium carbonate; In Isopropyl acetate; at 23 ℃; for 24h; Resolution of racemate;

DOI:10.1039/c2cc34907h

Reference yield:

(S)-piperidine-2-ethanol (S)-(+)-camphorsulfonate → (2S)-2-(2-methoxyethyl)piperidine (103639-57-2)

Guidance literature:

With sodium hydroxide; In water; for 2h;

Reference yield:

2(RS)-(2-hydroxyethyl)piperidine (1484-84-0) → (2S)-2-(2-methoxyethyl)piperidine (103639-57-2)

Guidance literature:

2(RS)-(2-hydroxyethyl)piperidine; With N-Ac-Leu; In tetrahydrofuran; methanol; at 15 - 55 ℃; for 3.5h;

With sodium hydroxide; In water; for 1.5h; Product distribution / selectivity;

upstream raw materials:

2(RS)-(2-hydroxyethyl)piperidine

Downstream raw materials:

benzyl (2S)-2-(2-hydroxyethyl)piperidine-1-carboxylate

Dinaciclib

(S)-2-(1-(6-(((6,7-difluoro-1H-benzo[d]imidazol-2-yl)methyl)amino)-9-isopropyl-9H-purin-2-yl)piperidin-2-yl)ethan-1-ol

(S)-1-methyl-N-(4-((2-(2-morpholinoethyl)piperidin-1-yl)sulfonyl)phenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide