2-Hexanone, 4-phenyl-

Base Information

• Chemical Name: 2-Hexanone, 4-phenyl-
• CAS No.: 68522-85-0
• Molecular Formula: C12H16O
• Molecular Weight: 176.258
• Mol file: 68522-85-0.mol

Synonyms:4-phenyl-hexan-2-one;(+/-)-4-phenyl-hexan-2-one;13-Oxo-1-(11-aetho-butyl)-benzol;rac-4-phenylhexan-2-one;4-Phenyl-hexan-2-on;4-phenyl-2-hexanone;

Chemical Property of 2-Hexanone, 4-phenyl-

Chemical Property:

• PSA: 17.07000
• LogP: 3.15930

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Hexanone, 4-phenyl-

There total 61 articles about 2-Hexanone, 4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

diethylzinc (557-20-0) + (E)-benzalacetone (1896-62-4) → 4-phenylhexan-2-one (68522-85-0)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); triethyl phosphite; In hexane; toluene; -20 deg C and 10 min, 0 deg C;

DOI:10.1016/S0040-4039(97)10068-5

Reference yield: 96.0%

diethylzinc (557-20-0) + 1-Phenylbut-1-en-3-one (122-57-6) → (R)-4-phenylhexan-2-one (16460-85-8,68522-85-0,115651-75-7)

Guidance literature:

diethylzinc; With C₅₄H₃₇N₂O₂P; copper(II) acetylacetonate; In toluene; at 0 ℃; for 0.5h; Inert atmosphere;

1-Phenylbut-1-en-3-one; In toluene; at 0 ℃; for 1h; enantioselective reaction; Inert atmosphere;

DOI:10.1055/s-0033-1338439

Reference yield: 94.0%

diethylzinc (557-20-0) + (E)-benzalacetone (1896-62-4) → (S)-4-phenylhexan-2-one (16460-85-8,68522-85-0,115651-75-7)

Guidance literature:

With copper(II) choride dihydrate; (R)-BINOL-XPHOS; In tetrahydrofuran; at -20 ℃; for 16h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/anie.200906839

upstream raw materials:

ethylmagnesium iodide

diethyl ether

1-Phenylbut-1-en-3-one

ethylmagnesium bromide

Downstream raw materials:

3-Methyl-5-phenyl-heptan-3-ol