1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-methyl-1-(phenylmethyl)-

Base Information

• Chemical Name: 1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-methyl-1-(phenylmethyl)-
• CAS No.: 68827-40-7
• Molecular Formula: C12H11ClN2O
• Molecular Weight: 234.685
• DSSTox Substance ID: DTXSID60368658
• Nikkaji Number: J452.130G
• Wikidata: Q82155372
• Mol file: 68827-40-7.mol

Synonyms:68827-40-7;1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-methyl-1-(phenylmethyl)-;1-benzyl-5-chloro-3-methylpyrazole-4-carbaldehyde;1-benzyl-5-chloro-4-formyl-3-methylpyrazole;SCHEMBL964648;DTXSID60368658;AKOS001053131;EN300-04834;A898170;Z56922064;1-benzyl-5-chloro-3-methyl-1h-pyrazole-4-carbaldehyde;5-Chloro-1-benzyl-3-methyl-1H-pyrazole-4-carbaldehyde;T0517-6127

Chemical Property of 1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-methyl-1-(phenylmethyl)-

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 234.0559907
• Heavy Atom Count: 16
• Complexity: 243

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NN(C(=C1C=O)Cl)CC2=CC=CC=C2

Technology Process of 1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-methyl-1-(phenylmethyl)-

There total 2 articles about 1H-Pyrazole-4-carboxaldehyde, 5-chloro-3-methyl-1-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzylhydrazine (555-96-4) → 1-benzyl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde (68827-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / diethyl ether / 1.5 h / 0 - 20 °C

2: trichlorophosphate / 2.5 h / 0 - 120 °C

With triethylamine; trichlorophosphate; In diethyl ether;

DOI:10.24820/ark.5550190.p010.934

Reference yield:

→ 1-benzyl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde (68827-40-7)

Guidance literature:

Reference yield: 27.0%

3,5-Dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester (35691-93-1) + 1-benzyl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde (68827-40-7) → ethyl 1-benzyl-3,7-dimethyl-1H-dipyrazolo[1,5-a:4',3'-e]pyridine-6-carboxylate (1422280-91-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 8h;

DOI:10.1039/c2ob27050a

upstream raw materials:

Benzylhydrazine

Downstream raw materials:

2-Benzyl-5-methyl-4-[1-methylamino-meth-(Z)-ylidene]-2,4-dihydro-pyrazole-3-thione

2-Benzyl-4-[1-isopropylamino-meth-(Z)-ylidene]-5-methyl-2,4-dihydro-pyrazole-3-thione

2-Benzyl-4-[1-benzylamino-meth-(Z)-ylidene]-5-methyl-2,4-dihydro-pyrazole-3-thione

2-Benzyl-4-[1-cyclohexylamino-meth-(Z)-ylidene]-5-methyl-2,4-dihydro-pyrazole-3-thione