35691-93-1

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 3,5-DIMETHYL-1H-4-PYRAZOLECARBOXYLATE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, ETHYL 3,5-DIMETHYL-1H-4-PYRAZOLECARBOXYLATE is employed as an intermediate in the production of agrochemicals, aiding in the creation of compounds that can enhance crop protection and management.
ETHYL 3,5-DIMETHYL-1H-4-PYRAZOLECARBOXYLATE is used as a chemical intermediate for the synthesis of various organic compounds due to its reactivity and functional group compatibility in chemical reactions, facilitating the creation of a wide range of products across different industries.

InChI:InChI=1/C8H12N2O2/c1-4-12-8(11)7-5(2)9-10-6(7)3/h4H2,1-3H3,(H,9,10)

Upstream product

• 603-69-0 ethyl 2-acetylacetoacetate 
• 99181-91-6 ethyl 2-acetyl-3-ethoxybut-2-enoate 

Downstream Products

• 89600-69-1 4-hydroxymethyl-3,5-dimethyl-1H-pyrazole 
• 94009-31-1 ethyl 1-(2-nitrobenzyl)-3,5-dimethylpyrazole-4-carboxylate 
• 1590405-75-6 ethyl 2-methyl-5-phenylpyrazolo[1,5-a]quinoline-3-carboxylate 
• 1590405-94-9 ethyl 1-(cyano-4-methylphenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylate 
• 1590405-96-1 ethyl 1-(2-cyano-4-methoxylphenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylate 
• 1014702-45-4 (5-{2-[1-(3,3-difluoro-cyclobutanecarbonyl)-3-phenyl-pyrrolidin-3-yl]-ethyl}-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-(3,5-dimethyl-1-pyrimidin-5-yl-1H-pyrazol-4-yl)-methanone 
• 1014703-06-0 C₃₃H₄₃N₇O₃ 
• 1014703-42-4 C₂₈H₃₅N₇O 
• 89193-14-6 ethyl 2-methyl-5,7-diphenylpyrazolo[1,5-a]pyridine-3-carboxylate 
• 1313197-34-0 N-(2-hydroxyethyl)-3,5-dimethyl-1-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1H-pyrazole-4-carboxamide 
• 1313197-33-9 N-(2-methoxyethyl)-3,5-dimethyl-1-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1H-pyrazole-4-carboxamide 
• 1313196-35-8 3,5-dimethyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxylic acid 
• 113808-86-9 3,5-dimethyl-1H-pyrazole-4-carboxylic acid 
• 1422280-91-8 ethyl 1-benzyl-3,7-dimethyl-1H-dipyrazolo[1,5-a:4',3'-e]pyridine-6-carboxylate 

Relevant academic research and scientific papers

Study of the Reaction of 2-(1-Alkoxyalkylidene)-1,3-dicarbonyl Compounds with Hydrazines

13C NMR study has shown that the only site of primary attack by hydrazines on alkyl 3-oxobutanoates containing an alkoxymethylene or 1-alkoxyethylidene group in position 2 is the ethylenic carbon atom and that the corresponding enehydrazine is the only observable intermediate product. According to quantum-chemical calculations of the electronic structure of the substrates, the reaction is orbital-controlled.

Study of the reaction of 2-acyl 1,3-dicarbonyl compounds with hydrazines by 1H NMR spectroscopy

The reaction of 2-acyl 1,3-dicarbonyl compounds with hydrazine and phenylhydrazine was studied by 1H NMR spectroscopy.It was shown that the formation of functionally 4-substituted pyrazoles is promoted if the reaction is conducted in protic solvents at reduced temperature.The presence of the benzoyl groups in the 2-acyl 1,3-dicarbonyl compounds leads to the preferential formation of the cleavage products, i.e., the corresponding acylhydrazines and 1,3-dicarbonyl compounds.It was established that the initial reaction product is consumed in two directions, i.e., cyclization with the formation of functionally 4-substituted pyyrazoles and cleavage with the formation of acetylhydrazines and the corresponding 1,3-dicarbonyl compounds.