Cyclopenin

Base Information

Chemical Name:Cyclopenin
CAS No.:19553-26-5
Molecular Formula:C₁₇H₁₄N₂O₃
Molecular Weight:294.31
Hs Code.:

Synonyms:CYCLOPENIN;(-)(rel 3R,3'S)-4-Methyl-3'-phenyl-1H-spiro[benzo[e][1,4]diazepin-3,2'-oxiran]-2,5-dion;

Suppliers and Price of Cyclopenin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
rel-Isocyclopenine
1mg
$ 1375.00

Adipogen Life Sciences
Cyclopenin ≥98%(HPLC)
5 mg
$ 380.00

Total 7 raw suppliers

Chemical Property of Cyclopenin

Chemical Property:

Boiling Point:572.5±50.0 °C(Predicted)
PKA:12.92±0.40(Predicted)
PSA：61.94000
Density:1.40±0.1 g/cm3(Predicted)
LogP:2.25440

Purity/Quality:

98%Min ^*data from raw suppliers

rel-Isocyclopenine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Cyclopenin is one of an unusual family of benzodiazepine metabolites produced by a number of Penicillium species. Often mistakenly referred to as a mycotoxin, cyclopenin shows little toxicity against mammalian cells, bacteria or fungi in vitro. Cyclopenin is an intermediate in the biosynthesis of 3-O-methyl viridicatin, a strong inhibitor of TNFα-induced replication HIV. Lack of availability has hitherto restricted a more intensive investigation of this interesting metabolite. (±)-Isocyclopenine is the racemic form of metabolites of natural product cyclopeptine (C991620) isolated from Penicillium cyclopium. Intermediate in the biosynthesis of the viridicatins.

Technology Process of Cyclopenin

There total 9 articles about Cyclopenin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 19113-24-7
(Z)-3-benzylidene-4-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

: 19357-57-4,19553-26-5,20007-87-8,25273-38-5
4-methyl-3'-phenylspiro[benzo[e][1,4]diazepine-3,2'-oxirane]-2,5(1H,4H)-dione

Guidance literature:: With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 72h; Reflux;
DOI:10.1002/anie.201710567

Reference yield:

: 31965-37-4
3-benzylidene-4-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

: 19357-57-4,19553-26-5,20007-87-8,25273-38-5
(-)-cyclopenin

Guidance literature:: With α-keto-glutarate (α-KG)-dependent iron(Fe/α-KG) enzyme AsqJ; oxygen; α-ketoglutarate; iron(II); In aq. buffer; at 6 ℃; Enzymatic reaction;
DOI:10.1021/jacs.6b05400