Ethyl [(3-chloro-4-fluorophenyl)amino](oxo)acetate

Base Information

Chemical Name:Ethyl [(3-chloro-4-fluorophenyl)amino](oxo)acetate
CAS No.:69066-02-0
Molecular Formula:C₁₀H₉ClFNO₃
Molecular Weight:245.638
Hs Code.:
DSSTox Substance ID:DTXSID90392244
Nikkaji Number:J1.871.902I
Wikidata:Q82190303

Synonyms:69066-02-0;Acetic acid, [(3-chloro-4-fluorophenyl)amino]oxo-, ethyl ester;ethyl [(3-chloro-4-fluorophenyl)amino](oxo)acetate;SCHEMBL11061164;DTXSID90392244;STK301246;AKOS005433990;Ethyl (3-chloro-4-fluoroanilino)(oxo)acetate;EN300-236361;2-(3-Chloro-4-fluorophenylamino)glyoxylic acid ethyl ester;ETHYL [(3-CHLORO-4-FLUOROPHENYL)CARBAMOYL]FORMATE

Suppliers and Price of Ethyl [(3-chloro-4-fluorophenyl)amino](oxo)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Ethyl [(3-chloro-4-fluorophenyl)amino](oxo)acetate

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:245.0254990
Heavy Atom Count:16
Complexity:275

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(=O)NC1=CC(=C(C=C1)F)Cl

Technology Process of Ethyl [(3-chloro-4-fluorophenyl)amino](oxo)acetate

There total 2 articles about Ethyl [(3-chloro-4-fluorophenyl)amino](oxo)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 367-21-5
3-chloro-4-fluorophenylamine

: 95-92-1
oxalic acid diethyl ester

: 69066-02-0
ethyl 3'-chloro-4'-fluorooxanilate

Guidance literature:: In toluene; for 2h; Heating;
DOI:10.1021/jf025870+

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 4755-77-5
Ethyl oxalyl chloride

: 69066-02-0
ethyl 3'-chloro-4'-fluorooxanilate

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/jm3002247

Reference yield:

: 69066-02-0
ethyl 3'-chloro-4'-fluorooxanilate

: N₁-(3-chloro-4-fluorophenyl)-N₂-((5-(hydroxymethyl)-4-methylthiazol-2-yl)(piperidin-2-yl)methyl)oxalamide dihydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / ethanol

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide; In ethanol;
DOI:10.1021/jm3002247