1H-imidazo[4,5-b]pyrazine

Base Information

Chemical Name:1H-imidazo[4,5-b]pyrazine
CAS No.:273-94-9
Molecular Formula:C5H4 N4
Molecular Weight:120.114
Hs Code.:2933990090
European Community (EC) Number:837-971-2
NSC Number:151667
DSSTox Substance ID:DTXSID10421828
Nikkaji Number:J1.547.161A
Mol file:273-94-9.mol

Synonyms:1H-imidazo[4,5-b]pyrazine;273-94-9;imidazopyrazine;MFCD08669465;SCHEMBL42609;1H-imidazo[5,4-b]pyrazine;7H-imidazo[4,5-b]pyrazine;DTXSID10421828;ZKAMEFMDQNTDFK-UHFFFAOYSA-N;AMY37654;NSC151667;AKOS006291753;CS-W021326;DS-6300;NSC-151667;PB48662;SY025046;FT-0731587;EN300-257817;A876948;Z1198180623

Suppliers and Price of 1H-imidazo[4,5-b]pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
1H-Imidazo[4,5-b]pyrazine
1 g
$ 885.00

Crysdot
1H-Imidazo[4,5-b]pyrazine 97%
1g
$ 278.00

Chemenu
1H-imidazo[4,5-b]pyrazine 95%+
100mg
$ 123.00

Chemenu
1H-imidazo[4,5-b]pyrazine 95%+
250mg
$ 232.00

Apolloscientific
1H-Imidazo[4,5-b]pyrazine
1g
$ 802.00

American Custom Chemicals Corporation
1H-IMIDAZO[4,5-B]PYRAZINE 95.00%
5MG
$ 504.58

Ambeed
1H-Imidazo[4,5-b]pyrazine 97%
1g
$ 187.00

Ambeed
1H-Imidazo[4,5-b]pyrazine 97%
250mg
$ 75.00

Ambeed
1H-Imidazo[4,5-b]pyrazine 97%
100mg
$ 50.00

Alichem
1H-Imidazo[4,5-b]pyrazine
5g
$ 1557.92

Total 39 raw suppliers

Chemical Property of 1H-imidazo[4,5-b]pyrazine

Chemical Property:

Vapor Pressure:0.243mmHg at 25°C
Boiling Point:213.1°Cat760mmHg
PKA:5.78±0.20(Predicted)
Flash Point:74.2°C
PSA：54.46000
Density:1.61g/cm³
LogP:0.35290
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:120.043596145
Heavy Atom Count:9
Complexity:105

Purity/Quality:

99%, ^*data from raw suppliers

1H-Imidazo[4,5-b]pyrazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN=C2C(=N1)NC=N2

Technology Process of 1H-imidazo[4,5-b]pyrazine

There total 2 articles about 1H-imidazo[4,5-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 2-bromoimidazopyrazine

: 98-80-6
phenylboronic acid

: 273-94-9
1H-imidazo[4,5-d]pyrazine

: 88710-42-3
2-phenyl-1H-imidazo[4,5-b]pyrazine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; In 1,2-dimethoxyethane; at 120 ℃; for 0.5h; Reagent/catalyst; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.cclet.2015.08.015

Reference yield:

: 16328-63-5
1H-imidazo<4,5-b>pyrazin-2(3H)-one

: 273-94-9
1H-imidazo[4,5-d]pyrazine

: 88710-42-3
2-phenyl-1H-imidazo[4,5-b]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus(V) oxybromide / 1,2-dichloro-ethane / 6 h / 80 °C / Inert atmosphere

2: cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; phosphorus(V) oxybromide; In 1,2-dimethoxyethane; 1,2-dichloro-ethane; 2: |Suzuki Coupling;
DOI:10.1016/j.cclet.2015.08.015