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Usage

Uses

Used in Pharmaceutical Research and Drug Development:
2H-Imidazo[4,5-b]pyrazin-2-one, 1,3-dihydrois utilized as a therapeutic agent in the treatment of various diseases and conditions due to its potential biological activities and pharmacological properties. Its unique chemical structure allows it to interact with biological targets, offering a promising avenue for the development of new medications.
Used in Organic Synthesis:
In the field of organic synthesis, 2H-Imidazo[4,5-b]pyrazin-2-one, 1,3-dihydrois employed as a building block for the preparation of other heterocyclic compounds. Its fused ring system provides a versatile template for the synthesis of diverse chemical entities, which can be further modified to explore their potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C5H4N4O/c10-5-8-3-4(9-5)7-2-1-6-3/h1-2H,(H2,6,7,8,9,10)

Upstream product

• 13134-31-1 pyrazine-2,3-diamine 
• 57-13-6 urea 
• 4744-50-7 2,3-pyrazinedicarboxylic anhydride 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 84996-64-5 2-methoxy-1-methyl-1H-imidazo<4,5-b>pyrazine 
• 84996-54-3 2-methoxy-4-methyl-4H-imidazo<4,5-b>pyrazine 
• 84996-55-4 1,4-dimethyl-1H-imidazo<4,5-b>pyrazin-2(4H)-one 
• 84996-53-2 1,3-dimethyl-1H-imidazo<4,5-b>pyrazin-2(3H)-one 
• 88710-42-3 2-phenyl-1H-imidazo[4,5-b]pyrazine 
• 273-94-9 1H-imidazo[4,5-d]pyrazine 
• 79100-21-3 1H-imidazo<4,5-b>pyrazine-2-thiol 
• 79100-25-7 1-<(1H-imidazo<4,5-b>pyrazin-2-yl)thiol>-2-propanone 
• 79100-29-1 2-(2,6-Dinitro-4-trifluoromethyl-phenylsulfanyl)-1H-imidazo[4,5-b]pyrazine 
• 102212-87-3 6-(phenylmethyl)-8-n-butyl-9-hydroxypyrazino<2',3':4,5>imidazo<1,2-a>pyrimidin-7(6H)-one sodium salt 

Relevant academic research and scientific papers

An easy one-step synthesis of imidazolin-2-ones from phthalic anhydrides and their antioxidant evaluation

Treatment of phthalic anhydride derivatives with trimethylsilyl azide affords benzimidazolin-2-ones in 45-91% yield, which is the result of two consecutive Curtius reactions. Within the series obtained, 1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one showed highest antioxidant activity.

A facile access for the synthesis of some C-2 substituted imidazopyrazines by utilizing the palladium catalyzed Suzuki cross-coupling reaction under microwave irradiation

A rapid, efficient, and facile synthesis of an assortment of C-2 substituted imidazopyrazines has been achieved by utilizing the palladium catalyzed Suzuki cross-coupling of 2-bromo-1H-imidazo[4,5-b]pyrazine with various boronic acids under microwave irradiation. The utilization of (A-taphos)2PdCl2 as a catalyst in combination with CsF as base and DME-H2O (4:1) as the solvent system at 100°C procured the diaryls in acceptable to excellent yields. Prominent features of this developed methodology include short reaction times, fewer side products, and exceptional tolerance to a wide variety of functional groups.

1H-Imidazopyrazines. III. 2-Thiols and Derivatives (1,2)

1H-Imidazopyrazine-2-thiols were prepared.Their chlorination, alkylation and cyclization reactions are discussed.