2-Furanpropanoic acid, tetrahydro-, methyl ester

Base Information

• Chemical Name: 2-Furanpropanoic acid, tetrahydro-, methyl ester
• CAS No.: 69248-88-0
• Molecular Formula: C8H14O3
• Molecular Weight: 158.197
• Mol file: 69248-88-0.mol

Synonyms:

Chemical Property of 2-Furanpropanoic acid, tetrahydro-, methyl ester

Chemical Property:

• PSA: 35.53000
• LogP: 1.11860

Purity/Quality:

99% ^*data from raw suppliers

methyl3-(oxolan-2-yl)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Furanpropanoic acid, tetrahydro-, methyl ester

There total 2 articles about 2-Furanpropanoic acid, tetrahydro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

methyl 3-(2-furyl)acrylate (58293-85-9) → methyl 3-(2-furyl)propionate (37493-31-5) + methyl 3-(tetrahydrofuran-2-yl)propanoate (69248-88-0)

Guidance literature:

With ammonium hydroxide; hydrogen; palladium on activated charcoal; In methanol; for 1.5h; Ambient temperature;

Reference yield: 24.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 3-(tetrahydrofuran-2-yl)propanoate (69248-88-0)

Guidance literature:

With Quinuclidine; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; In acetonitrile; at 27 ℃; for 24h; Irradiation;

DOI:10.1126/science.aac8555

Reference yield: 87.0%

methyl 3-(tetrahydrofuran-2-yl)propanoate (69248-88-0) → 3-(tetrahydrofuran-2-yl)propan-1-ol (767-08-8)

Guidance literature:

With tert-butyl alcohol; In tetrahydrofuran; electrolysis (Mg electrodes, LiClO₄);

DOI:10.1021/jo00030a003

upstream raw materials:

methyl 3-(2-furyl)acrylate

tetrahydrofuran

acrylic acid methyl ester

Downstream raw materials:

3-(tetrahydrofuran-2-yl)propan-1-ol