Ethyl 3-[bis(2-methoxyethyl)amino]-3-oxopropanoate

Base Information

Chemical Name:Ethyl 3-[bis(2-methoxyethyl)amino]-3-oxopropanoate
CAS No.:69540-85-8
Molecular Formula:C11H21NO5
Molecular Weight:
Hs Code.:
DSSTox Substance ID:DTXSID10709375
Wikidata:Q82644274

Synonyms:Ethyl 3-[bis(2-methoxyethyl)amino]-3-oxopropanoate;69540-85-8;DTXSID10709375

Suppliers and Price of Ethyl 3-[bis(2-methoxyethyl)amino]-3-oxopropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Ethyl 3-[bis(2-methoxyethyl)amino]-3-oxopropanoate

Chemical Property:

XLogP3:-0.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:247.14197277
Heavy Atom Count:17
Complexity:224

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC(=O)N(CCOC)CCOC

Technology Process of Ethyl 3-[bis(2-methoxyethyl)amino]-3-oxopropanoate

There total 1 articles about Ethyl 3-[bis(2-methoxyethyl)amino]-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111-95-5
Bis-(2-methoxyethyl)amine

: 105-53-3
diethyl malonate

: 69540-85-8
3-Bis(2-methoxyethyl)amino-3-oxopropanoic acid ethyl ester

Guidance literature:: at 150 ℃;

Reference yield:

: 69540-85-8
3-Bis(2-methoxyethyl)amino-3-oxopropanoic acid ethyl ester

: 247148-00-1
2-{3-[bis-(2-methoxy-ethyl)-amino]-isoxazol-5-yl}-5-methoxy-phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: POCl₃ / 0.5 h / 20 °C

1.2: 1,2-dichloro-ethane / 5 h / Heating

1.3: 34 percent / NaOAc*3H₂O; H₂O / 1.5 h / 70 °C

2.1: 75.2 percent / NH₂OH*HCl; pyridine / ethanol / 24 h / Heating

With pyridine; hydroxylamine hydrochloride; trichlorophosphate; In ethanol; 1.1: Substitution / 1.2: Substitution / 1.3: Cyclization / 2.1: Ring cleavage;
DOI:10.1016/S0014-827X(99)00051-8

Reference yield:

: 69540-85-8
3-Bis(2-methoxyethyl)amino-3-oxopropanoic acid ethyl ester

: [5-(2-ethoxy-4-methoxy-phenyl)-isoxazol-3-yl]-bis-(2-methoxy-ethyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: POCl₃ / 0.5 h / 20 °C

1.2: 1,2-dichloro-ethane / 5 h / Heating

1.3: 34 percent / NaOAc*3H₂O; H₂O / 1.5 h / 70 °C

2.1: 75.2 percent / NH₂OH*HCl; pyridine / ethanol / 24 h / Heating

3.1: 78.6 percent / KOH; H₂O / 2 h / 75 °C

With pyridine; potassium hydroxide; hydroxylamine hydrochloride; water; trichlorophosphate; In ethanol; 1.1: Substitution / 1.2: Substitution / 1.3: Cyclization / 2.1: Ring cleavage / 3.1: Etherification;
DOI:10.1016/S0014-827X(99)00051-8