dihydrocilostaMide

Base Information

• Chemical Name: dihydrocilostaMide
• CAS No.: 69592-33-2
• Molecular Formula: C20H28N2O3
• Molecular Weight: 344.44800
• Mol file: 69592-33-2.mol

Synonyms:

Chemical Property of dihydrocilostaMide

Chemical Property:

• Melting Point: 144 - 146 °C
• PSA: 58.64000
• LogP: 3.65940

Purity/Quality:

98.5% ^*data from raw suppliers

N-Cyclohexyl-N-methyl-4-((2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)oxy)butanamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dihydrocilostaMide

There total 9 articles about dihydrocilostaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

(E)-3-{2-Amino-5-[3-(cyclohexyl-methyl-carbamoyl)-propoxy]-phenyl}-acrylic acid (105763-72-2) → N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,4-tetrahydro-quinolin-6-yloxy)-butyramide (69592-33-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 3h; under 3102.9 Torr;

DOI:10.1021/jm00385a011

Reference yield:

N-methylcyclohexylamine (100-60-7) → N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,4-tetrahydro-quinolin-6-yloxy)-butyramide (69592-33-2)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. Na₂CO₃ / tetrahydrofuran / 1 h / Ambient temperature

2: 83 percent / pyridine / ethanol / Heating

3: FeSO₄, aq. conc. NH₃ / 0.25 h / Heating

4: 17 percent / H₂ / 10percent Pd/C / methanol / 3 h / 3102.9 Torr

With pyridine; ammonium hydroxide; hydrogen; sodium carbonate; iron(II) sulfate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;

DOI:10.1021/jm00385a011

Reference yield:

2-nitro-5-hydroxybenzaldehyde (42454-06-8) → N-Cyclohexyl-N-methyl-4-(2-oxo-1,2,3,4-tetrahydro-quinolin-6-yloxy)-butyramide (69592-33-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 95 percent / K₂CO₃ / dimethylformamide / 1 h / 100 °C

2: 96 percent / aq. KOH / ethanol

3: oxalyl chloride / benzene; dimethylformamide / 1 h / Ambient temperature

4: aq. Na₂CO₃ / tetrahydrofuran / 1 h / Ambient temperature

5: 83 percent / pyridine / ethanol / Heating

6: FeSO₄, aq. conc. NH₃ / 0.25 h / Heating

7: 17 percent / H₂ / 10percent Pd/C / methanol / 3 h / 3102.9 Torr

With pyridine; potassium hydroxide; ammonium hydroxide; oxalyl dichloride; hydrogen; sodium carbonate; potassium carbonate; iron(II) sulfate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm00385a011

upstream raw materials:

(E)-3-{2-Amino-5-[3-(cyclohexyl-methyl-carbamoyl)-propoxy]-phenyl}-acrylic acid

N-methylcyclohexylamine

2-nitro-5-hydroxybenzaldehyde

ethyl 4-((3-formyl-4-nitrophenyl)oxy)butyrate

Refernces