100-60-7

Basic information

• Product Name: N-Methylcyclohexylamine
• Synonyms: 1-Methylcyclohexylamine;Cyclohexanamine,N-methyl-;Cyclohexylamine, N-methyl-;Cyclohexylmethylamine;cyclohexyl-methyl-amine;Methylcyclohexylamine;methylcyclohexylamine,[corrosivelabel];methylcyclohexylamine,[flammableliquidandcorrosivelabels]
• CAS NO: 100-60-7
• Molecular Formula: C7H15N
• Molecular Weight: 113.2
• EINECS: 202-869-3
• Product Categories: pharmaceutical;fine chemicals
• Mol File: 100-60-7.mol
• Article Data: 99

Chemical Properties

• Melting Point: −9-−7 °C(lit.)
• Boiling Point: 149 °C(lit.)
• Flash Point: 85 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 0.868 g/mL at 25 °C(lit.)
• Vapor Density: 4 (vs air)
• Vapor Pressure: 11 mm Hg ( 40 °C)
• Refractive Index: n20/D 1.456(lit.)
• Storage Temp.: Flammables area
• Solubility: 54g/l
• PKA: 11.03±0.20(Predicted)
• Explosive Limit: 2.2-10.5%(V)
• Water Solubility: 5.4 g/100 mL (20 ºC)
• Sensitive: Air Sensitive
• BRN: 1523664
• CAS DataBase Reference: N-Methylcyclohexylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methylcyclohexylamine(100-60-7)
• EPA Substance Registry System: N-Methylcyclohexylamine(100-60-7)

Safety Data

• Hazard Codes: C
• Statements: 10-21/22-35-20/21/22
• Safety Statements: 16-26-36/37/39-45
• RIDADR: UN 2734 8/PG 2
• WGK Germany: 1
• RTECS: GX1529000
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 100-60-7(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless to yellow liquid

Uses

Different sources of media describe the Uses of 100-60-7 differently. You can refer to the following data:
1. Intermediate, solvent, acid acceptor.
2. N-Methylcyclohexanamine is a chemical reagent used in the synthesis of Mps1 kinase inhibitors used in cancer research. Also used in the synthesis of antituberculosis agents as indole-2-carboxamides.
3. N-Methylcyclohexylamine is used as a component of vulcanization accelerators, but the market size is relatively small.

Preparation

N-Methylcyclohexylamine can be prepared by a procedure similar to that used for cyclohexylamine, i.e., by hydrogenation of methylaniline over a supported nickel catalyst or from cyclohexanone and methylamine under hydrogenation conditions. Cyclohexylamine reacts with methanol over copper, zinc, or copper – calcium catalysts.

Definition

ChEBI: A secondary aliphatic amine having methyl and cyclohexyl as the two alkyl groups.

General Description

A water-white liquid. Slightly soluble in water and floats on water. A strong irritant to skin and eyes. Corrosive. Used as a solvent.

Air & Water Reactions

Flammable. Slightly soluble in water.

Reactivity Profile

METHYL CYCLOHEXYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Toxic. Strong irritant to tissue.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

InChI:InChI=1/C7H15N/c1-8-7-5-3-2-4-6-7/h7-8H,2-6H2,1H3/p+1

Synthetic route

cyclohexanone (108-94-1) + dimethyl amine (124-40-3) → N-methylcyclohexylamine (100-60-7) + N,N-dimethyl-cyclohexanamine (98-94-2) + cyclohexanol (108-93-0)

Conditions	Yield
With hydrogen at 160 - 220℃; under 67506.8 - 97509.8 Torr; for 100 - 1000h; Product distribution / selectivity;	A 0.1% B 96% C 0.5%
With hydrogen at 160 - 180℃; under 63756.4 - 97509.8 Torr; for 100 - 400h; Product distribution / selectivity;	A 0.1% B 94% C 2%

N-butylamine (109-73-9) + 3-methyl-2-(N-methylcyclohexylamino)benzothiazolium iodide → butyl-(3-methyl-3H-benzothiazol-2-ylidene)-amine (70038-63-0) + N-methylcyclohexylamine (100-60-7)

Conditions	Yield
at 25℃; for 3h;	A 95% B 83%
In dichloromethane at 25℃; for 3h;	A 95% B 83%

Cyclohexyl isocyanide (931-53-3) → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
With Zr12(μ3-O)5[(μ3-O)CoCl]8[(μ2-O)2(μ3-O)CoCl]3Li3(triphenyldicarboxylate)9; hydrogen In toluene at 110℃; under 30003 Torr; for 42h; Catalytic behavior; Inert atmosphere; Schlenk technique;	92%
With dimethyl sulfoxide In water at 100℃; Green chemistry;	65%

N-methylaniline (100-61-8) → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
With hydrogen In neat (no solvent) at 80℃; under 7600.51 Torr; for 24h; Catalytic behavior; Autoclave;	91%
With dichloro(μ-chloro)(μ-hydrido)bis(η-p-cymene)diruthenium(II); hydrogen In neat (no solvent) at 75℃; under 37503.8 Torr; for 24h;	80%
With lithium; methylamine

methylamine hydrochloride (593-51-1) + cyclohexanone (108-94-1) → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
With iridium bromide; zinc In 1,4-dioxane; water at 30℃; for 72h;	85%
With titanium(IV) isopropylate; sodium tetrahydroborate; triethylamine 1.) EtOH, 25 deg C, 10 h, 2.) EtOH, 25 deg C, 8 h; Yield given. Multistep reaction;

cyclohexanone (108-94-1) + methylamine (74-89-5) → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
With hydrogenchloride; Zr(BH4)2Cl2(dabco)2 In methanol for 1h; Heating;	78%
With D-glucose; glucose dehydrogenase CDX-901; imine reductase 48 from Rhizobium sullae; nicotinamide adenine dinucleotide phosphate In aq. buffer at 25℃; for 24h; pH=9; Enzymatic reaction;	66%
With sodium tetrahydroborate; lithium chloride In tetrahydrofuran; methanol Flow reactor; chemoselective reaction;	37%

methanol (67-56-1) + cyclohexylamine (108-91-8) → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
With rhodium(III) chloride hydrate; potassium tert-butylate at 130℃; for 48h; Sealed tube; High pressure;	75%
With thorium dioxide at 320℃;
rhodium hydrido (PEt3)3 complex for 10h;	99 % Chromat.
With platinum on carbon; hydrogen; sodium hydroxide at 130℃; under 30003 Torr; for 36h; Autoclave;	74 %Chromat.
With palladium 10% on activated carbon; potassium tert-butylate at 130℃; for 12h;

N-(6-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-N-methyl-hydroxylamine (141339-38-0) → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
With carbon disulfide In acetonitrile for 1.5h; Ambient temperature;	71%

chloromethyltriethoxysilane (15267-95-5) + cyclohexylamine (108-91-8) → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
Stage #1: chloromethyltriethoxysilane; cyclohexylamine at 87℃; for 18h; Stage #2: With water In ethanol for 48h; Heating; Further stages.;	68%

Cyclohexyl-phenylsulfanylmethyl-amine; hydrochloride → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether -60 degC -> room temp.;	67%

N-(benzenesulfenyl)-N-methylcyclohexylamine (138710-07-3) → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) In cyclohexane Heating;	53%
With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) In cyclohexane for 0.25h; Mechanism; Product distribution; Heating; other conditions: other solvent, no reagents and catalysts; other sulpenamides as starting material; Competitive reaction of C-SPh compound 11 with Bu3nH: comparison of the reactivities of N-SPh and C-SPh bonds;

cyclohexanone (108-94-1) + methylamine (74-89-5) → N-methylcyclohexylamine (100-60-7) + cyclohexanol (108-93-0)

Conditions	Yield
With hydrogenchloride; sodium tetrahydroborate In isopropyl alcohol at 20 - 30℃;	A 45% B 40%
With potassium hydroxide; potassium phosphate In water at 18 - 20℃; pH 12, electrochemical reaction;

cyclohexylamine (108-91-8) + carbonic acid dimethyl ester (616-38-6) → N-methylcyclohexylamine (100-60-7) + N,N-dimethyl-cyclohexanamine (98-94-2)

Conditions	Yield
With binder-free NaY zeolite Heating;	A 5% B n/a

diazomethane (186581-53-3, 908094-01-9) + cyclohexylamine (108-91-8) → N-methylcyclohexylamine (100-60-7) + N,N-dimethyl-cyclohexanamine (98-94-2)

Conditions	Yield
With boron trifluoride diethyl etherate

N,N-dimethyl-cyclohexanamine (98-94-2) → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
With sodium hydroxide; potassium hexacyanoferrate(III)
With diethyl ether; bromocyane und Erhitzen des hierbei erhaltenen Reaktionsprodukts mit wss. H2SO4;
With naphthalene-1,4-dicarbonitrile In methanol; acetonitrile for 0.166667h; UV-irradiation;	11 % Chromat.

N-cyclohexylformamide (766-93-8) → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

N-(cyanomethyl)cyclohexylamine (1074-58-4) → N-methylcyclohexylamine (100-60-7) + N-cyclohexylethylenediamine (5700-53-8)

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

N-methylaniline hydrochloride (2739-12-0) → N-methylcyclohexylamine (100-60-7) + N-Methyldicyclohexylamine (7560-83-0)

Conditions	Yield
With ethanol; platinum at 70℃; under 1520 - 2280 Torr; Hydrogenation;

4-methylamino-phenol; hydrochloride (22906-85-0) → N-methylcyclohexylamine (100-60-7) + 4-(methylamino)cyclohexanol (2987-05-5)

Conditions	Yield
With water; platinum under 2280 Torr; Hydrogenation.entsteht ein Gemisch von cis- und trans-Form;

N-Methylformamide (123-39-7) + cyclohexanone (108-94-1) → N-methylcyclohexylamine (100-60-7) + N-Methyldicyclohexylamine (7560-83-0)

Conditions	Yield
With formic acid

diethyl ether (60-29-7) + cyclohexylamine (108-91-8) + dimethyl sulfate (77-78-1) → N-methylcyclohexylamine (100-60-7) + N,N-dimethyl-cyclohexanamine (98-94-2)

cyclohexylamine (108-91-8) + dimethyl sulfate (77-78-1) → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
With diethyl ether

N-(α-phenylbenzylidene)cyclohexylamine (16770-34-6) + methyl iodide (74-88-4) → benzophenone (119-61-9) + N-methylcyclohexylamine (100-60-7)

Conditions	Yield
anschliessend beim Kochen mit 90prozentigem Alkohol;

N-chloromethylamine (6154-14-9) + cyclohexyl-dimethylborane (127146-33-2) → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
a) 0 deg C, 5-10 min, b) RT, 60 min; Yield given;

Diphenylmethane (101-81-5) + lithium cyclohexyl(methyl)amide (84602-11-9) → N-methylcyclohexylamine (100-60-7) + diphenylmethyllithium (881-42-5)

Conditions	Yield
In tetrahydrofuran at 30℃; Equilibrium constant;

triphenylmethane (519-73-3) + lithium cyclohexyl(methyl)amide (84602-11-9) → N-methylcyclohexylamine (100-60-7) + trityllithium (733-90-4)

Conditions	Yield
In tetrahydrofuran at 30℃; Equilibrium constant;

1,3,5-tricyclohexyl-[1,3,5]triazinane (6281-14-7) → N-methylcyclohexylamine (100-60-7)

Conditions	Yield
With hydrogenchloride; zinc

methanol (67-56-1) + cyclohexylamine (108-91-8) → N-methylcyclohexylamine (100-60-7) + N,N-dimethyl-cyclohexanamine (98-94-2)

Conditions	Yield
ruthenium trichloride; tri-n-butyl phosphite In 1,4-dioxane at 180℃; for 15h;	A 3 % Chromat. B 14 % Chromat.
With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)amino]ruthenium(II); hydrogen at 120℃; under 30003 Torr; for 24h; Glovebox;	A n/a B 31 %Spectr.
With C19H37IrN4(2+)*2Cl(1-)*2H2O; potassium carbonate at 50℃; for 17h; Reagent/catalyst; Inert atmosphere; Schlenk technique; Sealed tube;	A 14 %Chromat. B 61 %Chromat.
With hydrogen at 55℃; under 750.075 Torr; for 24h; Irradiation; Green chemistry;

Methyltrimethoxyphosphonium tetrafluoroborate (15294-11-8) + cyclohexylamine (108-91-8) → N-methylcyclohexylamine (100-60-7) + N,N-dimethyl-cyclohexanamine (98-94-2)

Conditions	Yield
for 12h; Ambient temperature; Yield given. Yields of byproduct given;

N-methylcyclohexylamine (100-60-7) + 2-(vinyloxy)ethyl isothiocyanate (59565-09-2) → 1-Cyclohexyl-1-methyl-3-(2-vinyloxy-ethyl)-thiourea (121612-59-7)

Conditions	Yield
	100%

N-methylcyclohexylamine (100-60-7) + 2-phenyl-1-(2-thioxothiazolidin-3-yl)ethan-1-one (65439-58-9) → N-cyclohexyl-N-methyl-2-phenylacetamide (74472-25-6)

Conditions	Yield
	100%
In dichloromethane for 0.0333333h; Ambient temperature;	100%

N-methylcyclohexylamine (100-60-7) + benzenesulfenyl chloride (931-59-9) → N-(benzenesulfenyl)-N-methylcyclohexylamine (138710-07-3)

Conditions	Yield
With triethylamine In diethyl ether for 0.166667h;	100%

N-methylcyclohexylamine (100-60-7) + bis(trichloromethyl) carbonate (32315-10-9) → N-methyl-N-cyclohexylaminocarbonyl chloride (35028-38-7)

Conditions	Yield
With pyridine In toluene	100%
With pyridine In toluene
With pyridine In dichloromethane at 20℃; for 2h;

methanol (67-56-1) + N-methylcyclohexylamine (100-60-7) → N,N-dimethyl-cyclohexanamine (98-94-2)

Conditions	Yield
chloro(cyclopentadienyl)bis(triphenylphosphine)ruthenium (II) at 100℃;	100%
With rhodium(III) chloride hydrate; potassium tert-butylate at 130℃; for 48h; Sealed tube; High pressure;	45%
With Ru(OAc)2(1,1′-bis(diisopropylphosphino)ferrocene)(CO); trifluoroacetic acid at 100℃; for 24h; Temperature; Inert atmosphere; Schlenk technique;
With palladium 10% on activated carbon; potassium tert-butylate at 130℃; for 14h;

N-methylcyclohexylamine (100-60-7) → N-nitroso-N-methylcyclohexylamine (5432-28-0)

Conditions	Yield
With trichloroisocyanuric acid; silica gel; sodium nitrite In dichloromethane at 20℃; for 0.25h;	99%
With sulfuric acid; silica gel; sodium nitrite In dichloromethane at 20℃; for 0.166667h;	98%
With N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide; water; silica gel; sodium nitrite In dichloromethane at 20℃; for 0.0666667h; Reagent/catalyst;	98%

N-methylcyclohexylamine (100-60-7) + 1-(2-Thioxo-thiazolidin-3-yl)-hexadecan-1-one (74058-64-3) → N-cyclohexyl-N-methylhexadecanamide (74058-73-4)

Conditions	Yield
In dichloromethane for 0.166667h; Ambient temperature;	99%

N-methylcyclohexylamine (100-60-7) + 2-bromobenzoic acid chloride (7154-66-7) → 2-bromo-N-cyclohexyl-N-methylbenzamide (349395-89-7)

Conditions	Yield
With triethylamine In dichloromethane for 2h; Ambient temperature;	99%
With N-ethyl-N,N-diisopropylamine In diethyl ether at 0 - 20℃; Inert atmosphere;	4.5 g

N-methylcyclohexylamine (100-60-7) + 4-chloro-1H-pyrrolo[2,3-d]pyrimidine (3680-69-1) → N-cyclohexyl-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (252722-30-8)

Conditions	Yield
In 1,4-dioxane at 110℃; for 9h; Microwave irradiation; Sealed tube;	99%
Stage #1: N-methylcyclohexylamine; 4-chloro-1H-pyrrolo[2,3-d]pyrimidine In tert-butyl alcohol at 100℃; for 24h; Stage #2: With hydrogenchloride In water; tert-butyl alcohol pH=1; Stage #3: With sodium hydroxide In water; tert-butyl alcohol pH=14;	88%
In tert-butyl alcohol at 85℃;

2,4,6-trimethyl-pyridine (108-75-8) + N-methylcyclohexylamine (100-60-7) + sulfuric acid (7664-93-9) + tetrabutylammomium bromide (1643-19-2) → N-Isobutenyloxycarbonyl-N-methylcyclohexylamine

Conditions	Yield
In 1,1,2,2-tetrachloroethylene	99%

N-methylcyclohexylamine (100-60-7) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → N-(2-bromobenzyl)-N-methylcyclohexylamine (92299-13-3)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide Inert atmosphere;	99%

2-chlorothiazole (3034-52-4) + N-methylcyclohexylamine (100-60-7) → N-cyclohexyl-N-methylthiazol-2-amine

Conditions	Yield
With C50H61Cl2N3Pd; potassium tert-butylate In 1,4-dioxane at 100℃; for 2h;	99%

2-chloro-1,3-benzoxazole (615-18-9) + N-methylcyclohexylamine (100-60-7) → N-cyclohexyl-N-methylbenzo[d]oxazol-2-amine (34173-49-4)

Conditions	Yield
With C50H61Cl2N3Pd; potassium tert-butylate In 1,4-dioxane at 100℃; for 2h;	99%

N-methylcyclohexylamine (100-60-7) + zirconium(IV) chloride (10026-11-6) → tetrakis(cyclohexylmethylamide)zirconium (610786-42-0)

Conditions	Yield
With Li-n-Bu In hexane; toluene in oxygen and moisture free atmosphere; soln. of ligand in toluene addeddropwise to soln. of Li-n-Bu in hexane; stirred at room temp. for 2.5 h ; ZrCl4 added gradually for 30 min; stirred for 18 h; filtered; filtrate reduced to oil under reduced pressure; elem. anal.;	98.7%

indole (120-72-9) + N-methylcyclohexylamine (100-60-7) + dichloromethane (75-09-2) → Cyclohexyl-(1H-indol-3-ylmethyl)-methyl-amine

Conditions	Yield
In methanol at 50℃; under 6000480 Torr; for 96h;	98%

N-methylcyclohexylamine (100-60-7) + methyl 2-isothiocyanatobenzoate (16024-82-1) → methyl 2-(3-cyclohexyl-3-methylthioureido)benzoate (905486-98-8)

Conditions	Yield
In dichloromethane at 20℃; for 3h;	98%
In dichloromethane at 20℃;

5-methyl-1,3-benzoxazole (10531-78-9) + N-methylcyclohexylamine (100-60-7) → N-cyclohexyl-N'-(2-hydroxy-5-methylphenyl)-N-methylmethanimidamide (1323158-79-7)

Conditions	Yield
at 80℃; for 12h;	98%
In acetonitrile at 80℃; for 10h;

N-methylcyclohexylamine (100-60-7) + 2-Iodobenzoyl chloride (609-67-6) → N-cyclohexyl-2-iodo-N-methylbenzamide (1083239-65-9)

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 5h;	98%

N-methylcyclohexylamine (100-60-7) + 1-tosyl-4-vinyl-1,4-dihydro-2H-benzo[d] [1,3]oxazin-2-one (1038502-72-5) → (S)-N-(2-(1-(cyclohexyl(methyl)amino)allyl)phenyl)-4-methylbenzenesulfonamide

Conditions

Yield

Stage #1: N-methylcyclohexylamine With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 1-((11bS)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-1,2,3,4-tetrahydroquinoline In tetrahydrofuran at -10 - 20℃; for 0.166667h; Schlenk technique; Inert atmosphere; Stage #2: 1-tosyl-4-vinyl-1,4-dihydro-2H-benzo[d] [1,3]oxazin-2-one In tetrahydrofuran at -10℃; for 5h; Schlenk technique; Inert atmosphere; enantioselective reaction;

98%

N-methylcyclohexylamine (100-60-7) + ethyl 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (227617-16-5) → ethyl 4-(cyclohexyl(methyl)amino)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Conditions	Yield
In ethanol at 80℃; for 2h; Inert atmosphere;	98%

N-methylcyclohexylamine (100-60-7) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl cyclohexyl(methyl)carbamate

Conditions	Yield
With saccharin sulfonic acid In hexane at 20℃; for 1h;	97%
With piperazine functionalized zirconium-Fe3O4-MCM-41 magnetic nanoparticles In neat (no solvent) at 20℃; for 0.166667h; Time;	91%
With 1,3-disulfonic acid imidazolium hydrogen sulfate In neat (no solvent) at 20℃; for 0.166667h; Green chemistry; chemoselective reaction;	90%

N-methylcyclohexylamine (100-60-7) + Propiolic acid (471-25-0) → N-cyclohexyl-N-methylpropiolamide (1309932-49-7)

Conditions	Yield
Stage #1: Propiolic acid With pivaloyl chloride; potassium carbonate In tetrahydrofuran for 1h; Inert atmosphere; Cooling; Stage #2: N-methylcyclohexylamine In tetrahydrofuran for 1h; Inert atmosphere;	97%

potassium cyanate (590-28-3) + N-methylcyclohexylamine (100-60-7) + para-nitrophenyl bromide (586-78-7) → 1-cyclohexyl-3-(4-nitrophenyl)-1-methyl-urea (1442042-63-8)

Conditions	Yield
With copper(I) oxide; 2-(2,6-dimethylphenyl-amino)-2-oxoacetic acid potassium salt In acetonitrile at 110℃; Schlenk technique; Inert atmosphere;	97%

iodobenzene (591-50-4) + N-methylcyclohexylamine (100-60-7) → N-cyclohexyl-N-methylaniline (18707-43-2)

Conditions	Yield
With [Pd{C6H4(CH2N(CH2Ph)2)}(μ-Br)]2; potassium hydroxide In dimethyl sulfoxide at 120℃; for 0.5h;	97%
With sodium t-butanolate In dimethyl sulfoxide at 110℃; for 12h; Buchwald-Hartwig Coupling; Green chemistry;	95%
With sodium t-butanolate In dimethyl sulfoxide at 110℃; for 12h; Buchwald-Hartwig Coupling;	87%
With potassium hydroxide In dimethyl sulfoxide at 120℃; for 0.666667h;	75%
With copper(l) iodide; cesium fluoride In dimethyl sulfoxide at 130℃; for 24h; Ullmann Condensation; Inert atmosphere; Glovebox;

formaldehyd (50-00-0) + N-methylcyclohexylamine (100-60-7) + β-naphthol (135-19-3) → N-[methyl(2-naphthyl)]-N-methyl-N-cyclohexylamine

Conditions	Yield
In methanol; water for 0.25h; Inert atmosphere;	97%

N-methylcyclohexylamine (100-60-7) + ethyl 2-isothiocyanato-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (85716-87-6) → 2-(3-Cyclohexyl-3-methyl-thioureido)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester (207743-82-6)

Conditions	Yield
In dichloromethane for 5h; Ambient temperature;	96%
In dichloromethane at 20℃; for 3h;

N-methylcyclohexylamine (100-60-7) + cyclohexanone (108-94-1) → N-cyclohexyl-N-methylcyclohex-1-enamine (62372-47-8)

Conditions	Yield
With titanium tetrachloride In cyclohexane at 0 - 20℃; Inert atmosphere;	96%

N-methylcyclohexylamine (100-60-7) + o-bromobenzenesulfonyl chloride (2905-25-1) → 2-bromo-N-cyclohexyl-N-methylbenzenesulfonamide (1022649-92-8)

Conditions	Yield
With dmap; triethylamine In tetrahydrofuran at 20℃; for 16h; Inert atmosphere;	96%

N-methylcyclohexylamine (100-60-7) + 4-tert-butylphenyl triflate (154318-75-9) → C17H27N*ClH

Conditions	Yield
Stage #1: N-methylcyclohexylamine; 4-tert-butylphenyl triflate With potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); XPhos In tetrahydrofuran at 80℃; for 16h; Buchwald-Hartwig Coupling; Inert atmosphere; Sealed tube; Stage #2: With hydrogenchloride In diethyl ether Inert atmosphere;	96%

Upstream product

• 108-94-1 Cyclohexanone 
• 7429-90-5 Aluminium 

Downstream Products

• 611-75-6 Bromhexine hydrochloride 

Recommend Products

• 98-94-2  N,N-dimethyl-cyclohexanamine 
• 186581-53-3  diazomethane 
• 108-91-8  cyclohexylamine 
• 31121-10-5  2-(cyclohexyl-methyl-amino)-1-phenyl-ethanol 
• 96-09-3  styrene oxide 
• 96517-08-7  2-(cyclohexyl(methyl)amino)acetonitrile 
• 50-00-0  formaldehyd 
• 62316-86-3  cyclohexyl-methyl-amine; toluene-4-sulfonate 
• 536-57-2  p-toluene sulfinic acid 
• 73393-40-5  2-amino-N-cyclohexyl-N-methylbenzamide 
• 118-48-9  isatoic anhydride 
• 21510-59-8  trichloromethylphosphonyl dichloride 
• 1647-26-3  1-bromo-2-cyclohexylethane 
• 60439-16-9  1-bromo-4-cyclohexylbutane 

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In order to detect cyclohexylamine and N-methylcyclohexylamine simultaneously in urine, a gas chromatographic method was developed in which Chromosorb 103 (porous polymer) was found to be suitable as the column packing. The detection limits were 0.1 μg/ml of cyclohexylamine and 0.4 μg/ml of N-...detailed

The study of physico-chemical properties of binary systems consisting of N-Methylcyclohexylamine (cas 100-60-7) with 2-alkanols at T = (298.15–328.15) K07/19/2019

In this work, densities, ρ and refractive indices, nD of N-Methylcyclohexylamine + 2-alkanols have been measured over the entire range of composition at four temperatures 298.15, 308.15, 318.15 and 328.15 K and ambient pressure (81.5 kPa), using Anton Paar DMA 4500 oscillating densimeter and An...detailed