Acetamide, 2-(acetylamino)-N-(phenylmethyl)-

Base Information

• Chemical Name: Acetamide, 2-(acetylamino)-N-(phenylmethyl)-
• CAS No.: 69753-67-9
• Molecular Formula: C11H14N2O2
• Molecular Weight: 206.244
• DSSTox Substance ID: DTXSID30431560
• Nikkaji Number: J1.591.265K
• Wikidata: Q82245476
• ChEMBL ID: CHEMBL153559

Synonyms:Acetamide, 2-(acetylamino)-N-(phenylmethyl)-;69753-67-9;acetamido-N-benzylacetamide;CHEMBL153559;SCHEMBL7529131;DTXSID30431560;AKOS008572249

Chemical Property of Acetamide, 2-(acetylamino)-N-(phenylmethyl)-

Chemical Property:

• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 206.105527694
• Heavy Atom Count: 15
• Complexity: 223

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NCC(=O)NCC1=CC=CC=C1

Technology Process of Acetamide, 2-(acetylamino)-N-(phenylmethyl)-

There total 8 articles about Acetamide, 2-(acetylamino)-N-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzylamine (100-46-9) + N-acetylglycine (543-24-8) → N-acetyl-N'-benzylglycineamide (69753-67-9)

Guidance literature:

N-acetylglycine; With N-chlorobenzotriazole; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 0.25h;

benzylamine; With triethylamine; at 20 ℃; for 1h;

DOI:10.1080/10426507.2015.1024313

Reference yield: 91.0%

2-azido-N-(phenylmethyl)acetamide (116433-53-5) + thioacetic acid S-[(diphenylphosphanyl)methyl] ester (324753-11-9) → N-acetyl-N'-benzylglycineamide (69753-67-9)

Guidance literature:

In tetrahydrofuran; water; at 20 ℃; for 12h;

DOI:10.1021/ol006739v

Reference yield: 81.0%

N-benzyl-2-aminoacetamide (39796-52-6) + acetic anhydride (108-24-7) → N-acetyl-N'-benzylglycineamide (69753-67-9)

Guidance literature:

In dichloromethane; for 6h; Ambient temperature;

DOI:10.1021/jm00386a021

upstream raw materials:

N-benzyl-2-aminoacetamide

acetic anhydride

benzylamine

2-azido-N-(phenylmethyl)acetamide

Downstream raw materials:

2-methyl-5-(N-benzylacetamido)oxazole

2-methyl-5-(N-benzyltrifluoroacetamido)oxazole

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