Carbamic acid, [(1R)-2-[[3-[[5-bromo-4-(2-propynyloxy)-2-pyrimidinyl]amino]-5-(hydroxy methyl)phenyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1R)-2-[[3-[[5-bromo-4-(2-propynyloxy)-2-pyrimidinyl]amino]-5-(hydroxy methyl)phenyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester
CAS No.:702679-40-1
Molecular Formula:C28H30BrN5O5
Molecular Weight:596.481
Hs Code.:

Carbamic acid,
[(1R)-2-[[3-[[5-bromo-4-(2-propynyloxy)-2-pyrimidinyl]amino]-5-(hydroxy
methyl)phenyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl
ester

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Chemical Property of Carbamic acid, [(1R)-2-[[3-[[5-bromo-4-(2-propynyloxy)-2-pyrimidinyl]amino]-5-(hydroxy methyl)phenyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(1R)-2-[[3-[[5-bromo-4-(2-propynyloxy)-2-pyrimidinyl]amino]-5-(hydroxy methyl)phenyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester

There total 1 articles about Carbamic acid, [(1R)-2-[[3-[[5-bromo-4-(2-propynyloxy)-2-pyrimidinyl]amino]-5-(hydroxy methyl)phenyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 702679-31-0
5-[[5-bromo-4-(prop-2-ynyloxy)pyrimidin-2-yl]amino]-3-[[(2R)-2-[[(1,1-dimethylethylethoxy)carbonyl]amino]-1-oxo-3-phenylpropyl]amino]benzoic acid

: 541-41-3
chloroformic acid ethyl ester

: 702679-40-1
1,1-dimethylethoxy [(1R)-2-[[3-[[5-bromo-4-(prop-2-ynyloxy)pyrimidin-2-yl]amino]-5-(hydroxymethyl)phenyl]amino]-2-oxo-1-(phenylmethyl)ethyl] carbamate

Guidance literature:: 5-[[5-bromo-4-(prop-2-ynyloxy)pyrimidin-2-yl]amino]-3-[[(2R)-2-[[(1,1-dimethylethylethoxy)carbonyl]amino]-1-oxo-3-phenylpropyl]amino]benzoic acid; chloroformic acid ethyl ester; With triethylamine; In tetrahydrofuran; at -10 - 0 ℃; for 0.25h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃;