(2-CHLOROPHENYL)(2-HYDROXYPHENYL)METHANONE

Base Information

• Chemical Name: (2-CHLOROPHENYL)(2-HYDROXYPHENYL)METHANONE
• CAS No.: 70288-96-9
• Molecular Formula: C13H9ClO2
• Molecular Weight: 232.666
• Mol file: 70288-96-9.mol

Synonyms:2-chloro-2'-hydroxy-benzophenone;2-Chlor-2'-hydroxy-benzophenon;2'-Chlor-2-hydroxy-benzophenon;Methanone, (2-chlorophenyl)(2-hydroxyphenyl)-;(2-chlorophenyl)(2-hydroxyphenyl)-methanone;

Chemical Property of (2-CHLOROPHENYL)(2-HYDROXYPHENYL)METHANONE

Chemical Property:

• Melting Point: 92°C
• PSA: 37.30000
• LogP: 3.27660

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-CHLOROPHENYL)(2-HYDROXYPHENYL)METHANONE

There total 8 articles about (2-CHLOROPHENYL)(2-HYDROXYPHENYL)METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(2-(2-chlorophenoxy)phenyl)-2-oxoacetic acid → (2-chlorophenyl)(2-hydroxyphenyl)methanone (70288-96-9)

Guidance literature:

With 1-acetoxy-1,2-benziodoxol-3-one; 9-(2-mesityl)-10-methylacridinium perchlorate; In acetone; at 25 ℃; for 12h; Irradiation; Schlenk technique; Molecular sieve;

DOI:10.1021/acs.orglett.9b00353

Reference yield: 87.0%

(2-chlorophenyl)(phenyl)methanone (5162-03-8) → (2-chlorophenyl)(2-hydroxyphenyl)methanone (70288-96-9)

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; trifluoroacetic acid; trifluoroacetic anhydride; at 100 ℃; regioselective reaction; Sealed tube;

DOI:10.1002/anie.201207458

Reference yield: 56.0%

(2-chlorophenyl)(phenyl)methanone (5162-03-8) → (2-chloro-6-hydroxyphenyl)(2-hydroxyphenyl)methanone (1428244-93-2) + (2-chlorophenyl)(2-hydroxyphenyl)methanone (70288-96-9)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; [bis(acetoxy)iodo]benzene; trifluoroacetic acid; trifluoroacetic anhydride; at 80 ℃; for 14h; regioselective reaction; Sealed tube;

DOI:10.1039/c3ob27457h

upstream raw materials:

5-tert-butyl-2'-chloro-2-methoxy-benzophenone

(2-chlorophenyl)(phenyl)methanone

2-hydroxybromobenzene

2-(tetrahydropyran-2-yloxy)phenyl bromide

Downstream raw materials:

C₁₇H₁₆ClNO₃

xanth-9-one