2-(2-bromophenoxy)tetrahydro-2H-pyran

Base Information

• Chemical Name: 2-(2-bromophenoxy)tetrahydro-2H-pyran
• CAS No.: 57999-46-9
• Molecular Formula: C11H13BrO2
• Molecular Weight: 257.127
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID40394950
• Mol file: 57999-46-9.mol

Synonyms:2-(2-bromophenoxy)tetrahydro-2H-pyran;57999-46-9;2-(2-bromophenoxy)oxane;2-(2'-Bromophenoxy)tetrahydro-2H-pyran;2-(2-bromophenoxy)tetrahydropyran;SCHEMBL954903;DTXSID40394950;PVDAGKNKQFWQDO-UHFFFAOYSA-N;AKOS024262369;1-(tetrahydropyran-2-yloxy)-2-bromobenzene;CS-0453839;FT-0768874;F79774

Chemical Property of 2-(2-bromophenoxy)tetrahydro-2H-pyran

Chemical Property:

• PSA: 18.46000
• LogP: 3.35450
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 256.00989
• Heavy Atom Count: 14
• Complexity: 175

Purity/Quality:

99% ^*data from raw suppliers

2-(2-bromophenoxy)tetrahydro-2H-pyran 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCOC(C1)OC2=CC=CC=C2Br

Technology Process of 2-(2-bromophenoxy)tetrahydro-2H-pyran

There total 2 articles about 2-(2-bromophenoxy)tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-hydroxybromobenzene (95-56-7) → 2-(tetrahydropyran-2-yloxy)phenyl bromide (57999-46-9)

Guidance literature:

With 3,4-dihydro-2H-pyran; pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.ejmech.2021.113211

Reference yield: 95.0%

3,4-dihydro-2H-pyran (110-87-2) + 2-hydroxybromobenzene (95-56-7) → 2-(tetrahydropyran-2-yloxy)phenyl bromide (57999-46-9)

Guidance literature:

pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 97.0%

2-(tetrahydropyran-2-yloxy)phenyl bromide (57999-46-9) + d7-N,N-dimethylformamide (4472-41-7,185990-36-7) → 2-α-deuterio-(tetrahydropyran-2-yloxy)benzaldehyde

Guidance literature:

2-(tetrahydropyran-2-yloxy)phenyl bromide; With n-butyllithium; In diethyl ether; hexane; at 0 ℃; for 2h;

d₇-N,N-dimethylformamide; In diethyl ether; hexane; at 20 ℃; for 8h;

DOI:10.1002/chem.200305629

upstream raw materials:

3,4-dihydro-2H-pyran

2-hydroxybromobenzene

Downstream raw materials:

2,5-Dimethyl-2-(2-hydroxyphenyl)-3,4-dihydro-2H-pyrrole 1-Oxide

1-[4-(2-Dimethylamino-ethoxy)-phenyl]-2-phenyl-1-[2-(tetrahydro-pyran-2-yloxy)-phenyl]-butan-1-ol

1-(4-methoxyphenyl)-1-<2-(tetrahydropyran-2-yloxy)phenyl>-2-phenyl-1-butanol

2-hydroxy-1-deuteroformylbenzene