1H-Imidazole-5-carboxylicacid,1-[[3-bromo-2-[2-[[(trifluoromethyl)sulfonyl]amino]phenyl]-5-benzofuranyl]methyl]-4-cyclopropyl-2-ethyl-

Base Information

Chemical Name:1H-Imidazole-5-carboxylicacid,1-[[3-bromo-2-[2-[[(trifluoromethyl)sulfonyl]amino]phenyl]-5-benzofuranyl]methyl]-4-cyclopropyl-2-ethyl-
CAS No.:146623-68-9
Molecular Formula:C25H21 Br F3 N3 O5 S
Molecular Weight:612.424
Hs Code.:
Mol file:146623-68-9.mol

1H-Imidazole-5-carboxylicacid,1-[[3-bromo-2-[2-[[(trifluoromethyl)sulfonyl]amino]phenyl]-5-benzofuranyl]methyl]-4-cyclopropyl-2-ethyl-

Synonyms:GR 141092

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Imidazole-5-carboxylicacid,1-[[3-bromo-2-[2-[[(trifluoromethyl)sulfonyl]amino]phenyl]-5-benzofuranyl]methyl]-4-cyclopropyl-2-ethyl-

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 1H-Imidazole-5-carboxylicacid,1-[[3-bromo-2-[2-[[(trifluoromethyl)sulfonyl]amino]phenyl]-5-benzofuranyl]methyl]-4-cyclopropyl-2-ethyl-

There total 14 articles about 1H-Imidazole-5-carboxylicacid,1-[[3-bromo-2-[2-[[(trifluoromethyl)sulfonyl]amino]phenyl]-5-benzofuranyl]methyl]-4-cyclopropyl-2-ethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 146623-66-7
ethyl 1-<<3-bromo-2-<2-<<(trifluoromethyl)sulfonyl>amino>phenyl>-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylate

: 146623-68-9
1-<<3-bromo-2-<2-<<(trifluoromethyl)sulfonyl>amino>phenyl>-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 50 ℃; for 3h;
DOI:10.1021/jm00045a016

Reference yield:

: 1025993-01-4
3-Cyclopropyl-2-nitro-3-oxo-propionic acid ethyl ester

: 146623-68-9
1-<<3-bromo-2-<2-<<(trifluoromethyl)sulfonyl>amino>phenyl>-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / H₂, AcCl / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

2: 24 percent / Et₃N / ethanol

3: 62 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

4: 98 percent / trifluoroacetic acid / CH₂Cl₂ / 16 h / Ambient temperature

5: 100 percent / Et₃N / CH₂Cl₂ / 0.75 h / -70 °C

6: 95 percent / aq. NaOH / methanol / 3 h / 50 °C

With sodium hydroxide; hydrogen; potassium carbonate; triethylamine; acetyl chloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016

Reference yield:

: 24922-02-9
Ethyl 3-cyclopropyl-3-oxopropionate

: 146623-68-9
1-<<3-bromo-2-<2-<<(trifluoromethyl)sulfonyl>amino>phenyl>-5-benzofuranyl>methyl>-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / aq. NaNO₂ / acetic acid / 4 h / Ambient temperature

2: 60 percent / H₂, AcCl / 5percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

3: 24 percent / Et₃N / ethanol

4: 62 percent / K₂CO₃ / dimethylformamide / 16 h / Ambient temperature

5: 98 percent / trifluoroacetic acid / CH₂Cl₂ / 16 h / Ambient temperature

6: 100 percent / Et₃N / CH₂Cl₂ / 0.75 h / -70 °C

7: 95 percent / aq. NaOH / methanol / 3 h / 50 °C

With sodium hydroxide; hydrogen; potassium carbonate; triethylamine; acetyl chloride; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00045a016