3-(4-Acetylphenyl)-6,8-dibromo-2-methylquinazolin-4(3H)-one

Base Information

• Chemical Name: 3-(4-Acetylphenyl)-6,8-dibromo-2-methylquinazolin-4(3H)-one
• CAS No.: 70298-45-2
• Molecular Formula: C₁₇H₁₂Br₂N₂O₂
• Molecular Weight: 436.102
• DSSTox Substance ID: DTXSID90499621
• Wikidata: Q82350577

Synonyms:70298-45-2;3-(4-Acetylphenyl)-6,8-dibromo-2-methylquinazolin-4(3H)-one;3-(4-acetylphenyl)-6,8-dibromo-2-methyl-3,4-dihydroquinazolin-4-one;DTXSID90499621

Chemical Property of 3-(4-Acetylphenyl)-6,8-dibromo-2-methylquinazolin-4(3H)-one

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 435.92450
• Heavy Atom Count: 23
• Complexity: 529

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=C(C=C(C=C2Br)Br)C(=O)N1C3=CC=C(C=C3)C(=O)C

Technology Process of 3-(4-Acetylphenyl)-6,8-dibromo-2-methylquinazolin-4(3H)-one

There total 3 articles about 3-(4-Acetylphenyl)-6,8-dibromo-2-methylquinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3,5-dibromobenzoic acid (609-85-8) → 3-(4-acetyl-phenyl)-6,8-dibromo-2-methyl-3H-quinazolin-4-one (70298-45-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1 h / Heating

2: piperidine / ethanol / 10 h / Heating

With piperidine; In ethanol;

Reference yield:

6,8-dibromo-2-methyl-3,1-benzoxazin-4(H)-one (40889-42-7) + p-aminobenzophenone (99-92-3) → 3-(4-acetyl-phenyl)-6,8-dibromo-2-methyl-3H-quinazolin-4-one (70298-45-2)

Guidance literature:

With piperidine; In ethanol; for 10h; Heating;

Reference yield:

→ 3-(4-acetyl-phenyl)-6,8-dibromo-2-methyl-3H-quinazolin-4-one (70298-45-2)

Guidance literature:

6,8-Dibromo-acetanthranil, p-Amidoacetophenon;

upstream raw materials:

6,8-dibromo-2-methyl-3,1-benzoxazin-4(H)-one

p-aminobenzophenone

2-amino-3,5-dibromobenzoic acid

Downstream raw materials:

6,8-dibromo-3-<4-<3-(4-chlorophenylamino)-1-oxopropyl>phenyl>-2-methyl-4(3H)-quinazolinone

2-[1,2-Bis-(4-chloro-phenylamino)-2-(4-hydroxy-3-methoxy-phenyl)-ethyl]-6,8-dibromo-3-{4-[3-(4-chloro-phenylamino)-propionyl]-phenyl}-3H-quinazolin-4-one

6,8-dibromo-3-<4-<3-(4-chlorophenylamino)-1-oxopropyl>phenyl>-2-<2-(4-hydroxy-3-methoxyphenyl)-1,2-dimorpholinoethyl>-4(3H)-quinazolinone

6,8-Dibromo-3-{4-[3-(4-chloro-phenylamino)-propionyl]-phenyl}-2-[2-(4-hydroxy-3-methoxy-phenyl)-1,2-bis-p-tolylamino-ethyl]-3H-quinazolin-4-one

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