2,2-Dimethyl-3-phenyl-3,4-dihydro-2H-1,4-benzoxazine

Base Information

Chemical Name:2,2-Dimethyl-3-phenyl-3,4-dihydro-2H-1,4-benzoxazine
CAS No.:70310-31-5
Molecular Formula:C16H17NO
Molecular Weight:239.317
Hs Code.:
DSSTox Substance ID:DTXSID80499655

Synonyms:70310-31-5;2,2-Dimethyl-3-phenyl-3,4-dihydro-2H-1,4-benzoxazine;DTXSID80499655

Suppliers and Price of 2,2-Dimethyl-3-phenyl-3,4-dihydro-2H-1,4-benzoxazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2,2-Dimethyl-3-phenyl-3,4-dihydro-2H-1,4-benzoxazine

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:239.131014166
Heavy Atom Count:18
Complexity:283

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C(NC2=CC=CC=C2O1)C3=CC=CC=C3)C

Technology Process of 2,2-Dimethyl-3-phenyl-3,4-dihydro-2H-1,4-benzoxazine

There total 4 articles about 2,2-Dimethyl-3-phenyl-3,4-dihydro-2H-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 70310-25-7
2,2-dimethyl-3-phenyl-2H-1,4-benzoxazine

: 70310-31-5
2,2-dimethyl-3,4-dihydro-3-phenyl-2H-1,4-benzoxazine

Guidance literature:: With sodium hypophosphite; palladium 10% on activated carbon; In tetrahydrofuran; water; at 20 ℃; for 24h; Reagent/catalyst;
DOI:10.1021/acs.joc.8b02867

Reference yield:

: 70310-20-2
2-methyl-2-(2-nitro-phenoxy)-1-phenyl-propan-1-one

: 70310-31-5
2,2-dimethyl-3,4-dihydro-3-phenyl-2H-1,4-benzoxazine

Guidance literature:: With sodium hypophosphite; palladium on activated charcoal; In tetrahydrofuran; water;
DOI:10.1055/s-1979-28629

Reference yield:

: 611-70-1
phenyl isopropyl ketone

: 70310-31-5
2,2-dimethyl-3,4-dihydro-3-phenyl-2H-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: aluminum (III) chloride; bromine / diethyl ether

2.1: potassium carbonate / acetone / 3 h / 20 °C

2.2: 6 h / Reflux

3.1: sodium hypophosphite; palladium 10% on activated carbon / water; tetrahydrofuran / 24 h / 20 °C

With aluminum (III) chloride; sodium hypophosphite; palladium 10% on activated carbon; bromine; potassium carbonate; In tetrahydrofuran; diethyl ether; water; acetone;
DOI:10.1021/acs.joc.8b02867