Benzoic acid, 4-methyl-, 2-pyridinylmethyl ester

Base Information

• Chemical Name: Benzoic acid, 4-methyl-, 2-pyridinylmethyl ester
• CAS No.: 70415-70-2
• Molecular Formula: C14H13NO2
• Molecular Weight: 227.263
• Mol file: 70415-70-2.mol

Synonyms:

Chemical Property of Benzoic acid, 4-methyl-, 2-pyridinylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid, 4-methyl-, 2-pyridinylmethyl ester

There total 3 articles about Benzoic acid, 4-methyl-, 2-pyridinylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-tolyl iodide (624-31-7) + 2-pyridylmethyl formate (401515-97-7) → pyridin-2-ylmethyl 4-methylbenzoate (70415-70-2)

Guidance literature:

With sodium hydrogencarbonate; dodecacarbonyl-triangulo-triruthenium; palladium dichloride; In N,N-dimethyl-formamide; at 135 ℃; for 6h;

DOI:10.1021/jo026591o

Reference yield: 84.0%

2-methylpyridine N-oxide (931-19-1) + 4-methyl-benzaldehyde (104-87-0) → pyridin-2-ylmethyl 4-methylbenzoate (70415-70-2)

Guidance literature:

With 1,10-Phenanthroline; copper(I) bromide dimethylsulfide complex; di-tert-butyl peroxide; In 1,2-dichloro-ethane; tert-butyl alcohol; at 120 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.7b03446

Reference yield:

→ pyridin-2-ylmethyl 4-methylbenzoate (70415-70-2)

Guidance literature:

2-Hydroxymethylpyridin, p-Methylbenzoylchlorid;

DOI:10.1021/jo01328a043

upstream raw materials:

4-tolyl iodide

2-pyridylmethyl formate

2-methylpyridine N-oxide

4-methyl-benzaldehyde