401515-97-7Relevant academic research and scientific papers
Method for preparing formate-type compound
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Paragraph 0039; 0047; 0048, (2018/07/30)
The invention discloses a method for preparing a formate-type compound. The method comprises the following steps of: adopting an alcohol-type compound and 1,3-dihydroxyacetone as reaction raw materials, and under the existence of a composite catalyst and an oxidant, reacting for 2-48 hours in a reaction medium in a reactor at a reaction temperature of 25-100 DEG C so as to obtain the formate-typecompound. The method disclosed by the invention is simple, and is mild in reaction condition, and by the method, a target product can be obtained by low cost and high yield; the used catalyst has highcatalytic activity, and is easily separated from a reaction system to be repeatedly used; the whole process is environment-friendly, and the reaction raw material (1,3-dihydroxyacetone) is easily converted from a side product (glycerol) of biodiesel, so that the utilization of the glycerol is promoted.
RAPAMYCIN ANALOG
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Paragraph 0095, (2018/09/08)
The present invention relates to a novel rapamycin analogue (e.g., of Formula I or Formula II), mixtures, methods for its production, and its use in cancer therapy (e.g., prevention and/or treatment).
Silica triflate as an efficient reagent for the chemoselective formylation of alcohols
Shirini, Farhad,Marjani, Katayoun,Nahzomi, Hossein Taherpour,Zolfigol, Mohammad Ali
, p. 1245 - 1251 (2008/02/05)
Silica triflate, as a new and stable silica-based reagent, is prepared by a reaction of silica gel with trifluoromethane sulfonyl chloride at room temperature. This reagent can be used for the efficient and selective formylation of alcohols in the presence of phenols in a relatively short reaction time and high yields under heterogeneous reaction conditions.
Formate as a CO surrogate for cascade processes: Rh-catalyzed cooperative decarbonylation and asymmetric Pauson-Khand-type cyclization reactions
Lee, Hang Wai,Chan, Albert S. C.,Kwong, Fuk Yee
, p. 2633 - 2635 (2008/02/08)
A rhodium-(S)-xyl-BINAP complex-catalyzed tandem formate decarbonylation and [2 + 2 + 1] carbonylative cyclization is described; this cooperative process utilizes formate as a condensed CO source, and the newly developed cascade protocol can be extended t
Investigations of the scope and mechanism of the tandem hydroesterification/lactonization reaction
Wang, Lijun,Floreancig, Paul E.
, p. 4207 - 4210 (2007/10/03)
(Chemical Equation Presented) Heating allylic and homoallylic alcohols and 2-pyridylmethyl formate in the presence of Ru3(CO)12 initiates a tandem sequence of hydroesterification and lactonization. Mechanistic studies suggest that regioselectivity and overall reaction efficiency are governed by the relative rates of reductive elimination and β-hydride elimination for the alkylruthenium intermediates.
A novel chelation-assisted hydroesterification of alkenes via ruthenium catalysis
Ko, Sangwon,Na, Youngim,Chang, Sukbok
, p. 750 - 751 (2007/10/03)
An efficient and catalytic protocol of hydroesterification of alkenes has been developed without a need for CO atmosphere. With the introduction of the 2-pyridyl moiety as a chelating group in formate, Ru3(CO)12-catalyzed activation of the formyl C-H bond of formate and subsequent addition of the intermediate to alkenes proceeded with almost complete suppression of decarbonylation. Stereoselectivity of the produced one-carbon elongated esters was good to excellent for the formation of the linear adduct depending on the bulkiness of the alkenes used. This procedure could be readily applied to a variety of olefins such as terminal, internal, cyclic, bicyclic, vinyl ether, and conjugated enone systems with high efficiency and selectivity. It was also amenable to a solvent-free condition. On the basis of the chelation-driven C-H bond activation of formate, a putative mechanism of the Ru-catalyzed hydroesterification of 2-pyridylmethyl formate has been proposed. Copyright
