2,4-DichloronicotinaMide

Base Information

• Chemical Name: 2,4-DichloronicotinaMide
• CAS No.: 70593-56-5
• Molecular Formula: C6H4Cl2N2O
• Molecular Weight: 191.01500
• Hs Code.: 2933399090
• Mol file: 70593-56-5.mol

Synonyms:2,4-DICHLOROPYRIDINE-3-CARBOXAMIDE;

Chemical Property of 2,4-DichloronicotinaMide

Chemical Property:

• Melting Point: 182 °C
• Boiling Point: 288.4±40.0 °C(Predicted)
• PKA: 13.56±0.50(Predicted)
• PSA: 55.98000
• Density: 1.524±0.06 g/cm3(Predicted)
• LogP: 2.18760

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

2,4-Dichloropyridine-3-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DichloronicotinaMide

There total 2 articles about 2,4-DichloronicotinaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-dichloropyridine-3-carbonyl chloride (607351-40-6) → 2,4-dichloro-nicotinic acid amide (70593-56-5)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2007.10.018

Reference yield:

→ 2,4-dichloro-nicotinic acid amide (70593-56-5)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; Einleiten von Ammoniak in die Loesung des Reaktionsprodukts in Benzol;

Reference yield: 84.0%

2,4-dichloro-nicotinic acid amide (70593-56-5) → 2,4-dichloro-3-cyanopyridine (180995-12-4)

Guidance literature:

With triethylamine; trifluoroacetic anhydride; In dichloromethane; at 0 ℃;

DOI:10.1016/j.tetlet.2010.11.108

upstream raw materials:

2,4-dichloropyridine-3-carbonyl chloride

Downstream raw materials:

2,4-dichloro-3-cyanopyridine

Refernces