180995-12-4

Basic information

• Product Name: 2,4-DICHLORO-3-CYANOPYRIDINE
• Synonyms: 2,4-DICHLORO-3-CYANOPYRIDINE;3-Cyano-2,4-dichloropyridine;2,4-Dichloronicotinonitrile;2,4-Dichloropyridine-3-carbonitrile;2,4-dichloro-3-Pyridinecarbonitrile
• CAS NO: 180995-12-4
• Molecular Formula: C₆H₂Cl₂N₂
• Molecular Weight: 172.99948
• Product Categories: Pyridine;Heterocycle-Pyridine series
• Mol File: 180995-12-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 293 °C at 760 mmHg
• Flash Point: 131 °C
• Appearance: /
• Density: 1.49 g/cm³
• Vapor Pressure: 0.00177mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.94±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2,4-DICHLORO-3-CYANOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-3-CYANOPYRIDINE(180995-12-4)
• EPA Substance Registry System: 2,4-DICHLORO-3-CYANOPYRIDINE(180995-12-4)

Safety Data

• RIDADR: 3439
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 180995-12-4(Hazardous Substances Data)

Usage

Uses

2,4-Dichloro-3-cyanopyridine, is used as a pharmaceutical intermediate.

InChI:InChI=1/C6H2Cl2N2/c7-5-1-2-10-6(8)4(5)3-9/h1-2H

Upstream product

• 89791-95-7 4-methoxy-nicotinic acid-1-oxide 
• 40899-41-0 4-methoxy-1-oxy-nicotinic acid methyl ester 
• 869802-74-4 2-chloro-4-oxo-1,4-dihydropyridine-3-carbonitrile 
• 180995-11-3 4-nitro-3-cyanopyridine N-oxide 
• 21642-98-8 4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 89694-06-4 4-methoxy-1-oxy-nicotinamide 
• 70593-56-5 2,4-dichloro-nicotinic acid amide 

Downstream Products

• 868065-71-8 2,4-di(cyclohexylthio)nicotinonitrile 
• 886457-60-9 4-(4-aminophenyl)-2-chloronicotinonitrile 
• 886457-61-0 2-(4-aminophenyl)-4-chloronicotinonitrile 

Relevant articles and documents

Reactivity and regioselectivity in Stille couplings of 3-substituted 2,4-dichloropyridines

The influence of substituents at C-3 of 2,4-dichloropyridines on their reactivity and regioselectivity in Pd-catalyzed cross-couplings is studied. As a model reaction, the (Ph3P)2PdCl2-catalyzed Stille coupling between 2-furyl(tributyl)tin and pyridines is chosen. Increased electron-withdrawing ability of a substituent at the pyridine 3-position improves the overall reactivity. Absolute selectivity for coupling at C-2 is achieved with an amino group at C-3, and the selectivity is totally reversed when the amino group is exchanged for a nitro substituent.

SUBSTITUTED PYRAZOLOPYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE

The disclosure relates to substituted pyrazolo-pyridines, compositions containing them, methods for the production thereof, and to their use as medicaments, in particular, as anticancer agents.

Novel kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.