Benzenesulfonamide, 5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-2-propyl-, monohydrochloride

Base Information

• Chemical Name: Benzenesulfonamide, 5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-2-propyl-, monohydrochloride
• CAS No.: 70958-67-7
• Molecular Formula: C21H30N2O3S.ClH
• Molecular Weight: 427.008
• Mol file: 70958-67-7.mol

Synonyms:

Chemical Property of Benzenesulfonamide, 5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-2-propyl-, monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenesulfonamide, 5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-2-propyl-, monohydrochloride

There total 6 articles about Benzenesulfonamide, 5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-2-propyl-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

5-{2-[Benzyl-(1-methyl-3-phenyl-propyl)-amino]-1-hydroxy-ethyl}-2-propyl-benzenesulfonamide (344754-62-7) → 5-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-2-propyl-benzenesulfonamide; hydrochloride (70958-67-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; Ambient temperature;

DOI:10.1248/cpb.30.4092

Reference yield:

3-amino-4-chloroacetophenone (79406-57-8) → 5-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-2-propyl-benzenesulfonamide; hydrochloride (70958-67-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) NaNO₂, cc HCl 2.) CuCl₂*2H₂O, SO₂ / 1.) AcOH, 5 deg C, 30 min 2.) AcOH, 0-5 deg C

2: cc NH₄OH / tetrahydrofuran / Ambient temperature

3: 73 percent / Bromine / acetic acid / 0.5 h / Ambient temperature

4: butan-2-one / 4 h / Heating

5: NaBH₄ / methanol / 2 h / Ambient temperature

6: 16 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; sulfur dioxide; hydrogen; bromine; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; butanone;

DOI:10.1248/cpb.30.4092

Reference yield:

4'-chloro-3'-sulfamoyl-acetophenone (2350-44-9) → 5-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-2-propyl-benzenesulfonamide; hydrochloride (70958-67-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / Bromine / acetic acid / 0.5 h / Ambient temperature

2: butan-2-one / 4 h / Heating

3: NaBH₄ / methanol / 2 h / Ambient temperature

4: 16 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

With sodium tetrahydroborate; hydrogen; bromine; palladium on activated charcoal; In methanol; acetic acid; butanone;

DOI:10.1248/cpb.30.4092

upstream raw materials:

5-{2-[Benzyl-(1-methyl-3-phenyl-propyl)-amino]-1-hydroxy-ethyl}-2-propyl-benzenesulfonamide

3-amino-4-chloroacetophenone

4'-chloro-3'-sulfamoyl-acetophenone

4'-chloro-3'-chlorosulfonylacetophenone