Phenol, 4-[(5-nitro-2-pyridinyl)oxy]-

Base Information

• Chemical Name: Phenol, 4-[(5-nitro-2-pyridinyl)oxy]-
• CAS No.: 71078-55-2
• Molecular Formula: C11H8N2O4
• Molecular Weight: 232.196
• DSSTox Substance ID: DTXSID00471392
• Wikidata: Q82299892

Synonyms:Phenol, 4-[(5-nitro-2-pyridinyl)oxy]-;71078-55-2;SCHEMBL10466511;DTXSID00471392

Chemical Property of Phenol, 4-[(5-nitro-2-pyridinyl)oxy]-

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 232.04840674
• Heavy Atom Count: 17
• Complexity: 261

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1O)OC2=NC=C(C=C2)[N+](=O)[O-]

Technology Process of Phenol, 4-[(5-nitro-2-pyridinyl)oxy]-

There total 7 articles about Phenol, 4-[(5-nitro-2-pyridinyl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(4-methoxyphenoxy)-5-nitropyridine (71973-03-0) → 2-(4-hydroxyphenoxy)-5-nitropyridine (71078-55-2)

Guidance literature:

With hydrogen bromide; tetrabutyl phosphonium bromide; at 100 ℃; for 11h;

DOI:10.1080/00397919308012606

Reference yield: 76.0%

5-[4-(benzyloxy)phenoxy]-2-nitropyridine (219766-77-5) → 2-(4-hydroxyphenoxy)-5-nitropyridine (71078-55-2)

Guidance literature:

With trifluoroacetic acid; In various solvent(s);

DOI:10.1016/j.bmc.2004.07.038

Reference yield:

2-chloro-5-nitropyridine (4548-45-2) + hydroquinone (123-31-9,8027-02-9) → 2-(4-hydroxyphenoxy)-5-nitropyridine (71078-55-2)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmc.2015.09.030

upstream raw materials:

2-(4-methoxyphenoxy)-5-nitropyridine

5-[4-(benzyloxy)phenoxy]-2-nitropyridine

2-chloro-5-nitropyridine

4-Benzyloxyphenol

Downstream raw materials:

5-nitro-2-[4-(thiophen-3-ylmethoxy)-phenoxy]-pyridine

5-Nitro-2-[4-(pyridin-2-ylmethoxy)-phenoxy]-pyridine

2-{4-[2-(3-fluoro-phenyl)-ethoxy]-phenoxy}-5-nitro-pyridine

2-(4-cyclohexylmethoxy-phenoxy)-5-nitro-pyridine

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