71973-03-0

Basic information

• Product Name: 2-(4-methoxyphenoxy)-5-nitropyridine
• Synonyms: 2-(4-methoxyphenoxy)-5-nitropyridine;2-(4-Methoxyphenoxy)-5-nitropyriMidine
• CAS NO: 71973-03-0
• Molecular Formula: C₁₂H₁₀N₂O₄
• Molecular Weight: 246.2188
• Mol File: 71973-03-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-methoxyphenoxy)-5-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenoxy)-5-nitropyridine(71973-03-0)
• EPA Substance Registry System: 2-(4-methoxyphenoxy)-5-nitropyridine(71973-03-0)

Safety Data

• Hazardous Substances Data: 71973-03-0(Hazardous Substances Data)

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 1122-95-8 sodium 4-methoxyphenolate 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 71078-55-2 2-(4-hydroxyphenoxy)-5-nitropyridine 
• 219865-99-3 6-(4-methoxyphenoxy)pyridin-3-amine 

Relevant articles and documents

Synergetic catalytic effect of rGO, Pd, Fe3O4 and PPy as a magnetically separable and recyclable nanocomposite for coupling reactions in green media

In this paper, rGO/Pd–Fe3O4@PPy as an efficient stable nanocomposite was synthesized. To understand the synergetic effects of rGO, Pd, Fe3O4 and PolyPyrrole, the performance of rGO/Pd–Fe3O4@PPy as a heterogeneous recyclable nanocatalyst in the green synthesis of C-C and C-O coupling products, as well as different conditions are studied. Synthesized rGO/Pd–Fe3O4@PPy was characterized by FT-IR, XRD, FE-SEM, EDS, TGA and AFM analysis. Best results are obtained under sonication in H2O for C-C coupling and by ball-milling for C-O coupling. The benefits of this method include: green solvents and conditions, absence of external base, low reaction times with high yield and easy work-up method.

Synthesis and structure-activity relationships of phenoxypyridine derivatives as novel inhibitors of the sodium-calcium exchanger

A series of 2-phenoxypyridine derivatives were prepared and evaluated for their inhibitory activity against the reverse and forward modes of the sodium-calcium exchanger (NCX). The structure-activity relationships of these compounds on the inhibitory activity for the sodium-calcium exchanger are discussed. The sodium-calcium exchanger (NCX) is known as the transporter that controls the concentration of Ca2+ in cardiac myocytes. In the setting of heart failure and myocardial ischemia-reperfusion, NCX underlies an arrhythmogenic transient inward current responsible for delayed after-depolarizations and nonreentrant initiation of ventricular tachycardia. NCX is an attractive target for treatment in heart failure and myocardial ischemia-reperfusion. We have designed and synthesized a series of phenoxypyridine derivatives, based on compound 3. These derivatives have been evaluated for their inhibitory activity against both the reverse and forward mode of NCX in CCL39 cells. We have discovered several novel potent NCX inhibitors (39q, 48k), which have a high selectivity for reverse NCX inhibitory activity.

Convenient Synthesis of Phenyl Pyridylethers Utilizing Fluoride Ion

Aryl pyridyl ethers were prepared from phenols and active halopyridines under essentially neutral condition via fluoride ion assisted reaction.