Lithium, [(phenylmethoxy)methyl]-

Base Information

• Chemical Name: Lithium, [(phenylmethoxy)methyl]-
• CAS No.: 71316-95-5
• Molecular Formula: C8H9LiO
• Molecular Weight: 128.1
• DSSTox Substance ID: DTXSID70449947
• Mol file: 71316-95-5.mol

Synonyms:Lithium, [(phenylmethoxy)methyl]-;benzyloxymethyllithium;benzyloxymethyl lithium;Benzyloxymethyl-Lithium;71316-95-5;SCHEMBL1041957;DTXSID70449947;NQGYDIOMIVPKOQ-UHFFFAOYSA-N

Chemical Property of Lithium, [(phenylmethoxy)methyl]-

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 128.08134334
• Heavy Atom Count: 10
• Complexity: 69.7

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [Li+].[CH2-]OCC1=CC=CC=C1

Technology Process of Lithium, [(phenylmethoxy)methyl]-

There total 4 articles about Lithium, [(phenylmethoxy)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

(p-methoxybenzyloxy)methyllithium → 4-C-Azidomethyl-5-O-[(4-methoxyphenyl)methyl]-2,3-di-O-(phenylmethyl)-1-(1,3-dithian-2-yl)-D-ribo-pentane + benzyloxymethyl lithium (71316-95-5)

Guidance literature:

Reference yield:

(Phenoxymethyl)tri-n-butylstannane (83693-60-1) → benzyloxymethyl lithium (71316-95-5)

Guidance literature:

With n-butyllithium;

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → benzyloxymethyl lithium (71316-95-5)

Guidance literature:

With n-butyllithium; sodium hydride; Yield given. Multistep reaction; 1.) THF, DMF, 2.) THF, Et₂O, -78 deg C, 50 min;

DOI:10.1021/ja00250a029

upstream raw materials:

benzyl alcohol

(Phenoxymethyl)tri-n-butylstannane

n-butyllithium

(benzyloxy)(trimethylstannyl)methane

Downstream raw materials:

3-<(benzyloxy)methyl>cyclohexan-1-one

3-benzyloxymethyl-cyclohex-2-enone

(4S,5R)-1-(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-<(2-methoxyethoxy)methoxy>-2-hexanone

rel-(4aS,8aS)-8a-<(benzyloxy)methyl>-1,4,4a,5,6,7,8,8a-octahydro-2(3H)-naphthalenone