3-HYDROXY-2-METHYL-4(1H)-PYRIDINONE

Base Information

• Chemical Name: 3-HYDROXY-2-METHYL-4(1H)-PYRIDINONE
• CAS No.: 17184-19-9
• Molecular Formula: C6H7 N O2
• Molecular Weight: 125.127
• Hs Code.: 2933399990
• Mol file: 17184-19-9.mol

Synonyms:4(1H)-Pyridone,3-hydroxy-2-methyl- (7CI,8CI); 2-Methyl-3-hydroxy-4(1H)-pyridone;2-Methyl-3-hydroxypyridine-4-one; 3-Hydroxy-2-methyl-1H-pyridin-4-one;3-Hydroxy-2-methyl-4(1H)-pyridinone; 3-Hydroxy-2-methyl-4(1H)-pyridone; CP 028;NSC 286640

Chemical Property of 3-HYDROXY-2-METHYL-4(1H)-PYRIDINONE

Chemical Property:

• Vapor Pressure: 0.00258mmHg at 25°C
• Melting Point: 300°
• Boiling Point: 254.8°Cat760mmHg
• PKA: 9.95±0.20(Predicted)
• Flash Point: 107.9°C
• PSA: 53.09000
• Density: 1.269g/cm³
• LogP: 0.38890
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly, Heated), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

N-Desmethyl Deferiprone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Desmethyl Deferiprone, is an impurity of Deferiprone (D474000), a chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transferrin and ferritin in vitro.

Technology Process of 3-HYDROXY-2-METHYL-4(1H)-PYRIDINONE

There total 6 articles about 3-HYDROXY-2-METHYL-4(1H)-PYRIDINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

Maltol (118-71-8) → 3-hydroxy-2-methylpyrid-4-one (17184-19-9)

Guidance literature:

Maltol; With ammonium hydroxide; at 40 ℃; for 2h;

With ammonium carbonate; at 40 ℃; for 10h; Reagent/catalyst; Temperature; Reflux;

Reference yield: 82.0%

3-benzyloxy-2-methyl-1H-pyridin-4-one (61160-18-7) → 3-hydroxy-2-methylpyrid-4-one (17184-19-9)

Guidance literature:

With hydrogen bromide; In acetic acid;

Reference yield: 77.0%

3-methoxy-2-methylpyridin-4(1H)-one (76015-11-7) → 3-hydroxy-2-methylpyrid-4-one (17184-19-9)

Guidance literature:

With hydrogen bromide; at 140 - 150 ℃; for 4h;

DOI:10.1002/jps.2600690923

upstream raw materials:

3-benzyloxy-2-methyl-1H-pyridin-4-one

3-methoxy-2-methylpyridin-4(1H)-one

Maltol

3-methoxy-2-methyl-4-pyrone

Downstream raw materials:

2-methyl-3,4-methylenedioxypyridine

2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride

2-hydroxymethyl-3,4-dimethoxypyridine

3,4-dimethoxy-2-methylpyridine N-oxide ?

Refernces

• 1、 Barta, Cheri A.,Sachs-Barrable, Kristina,Jia, Jessica,Thompson, Katherine H.,Wasan, Kishor M.,Orvig, Chris. "Lanthanide containing compounds for therapeutic care in bone resorption disorders". . p. 5019 - 5030. Retrieved 2007.
• 2、 -. "Application of 1-aryl-4-pyridone compound". Paragraph 0071-0072. . Retrieved 2020/01/12.