2-chloro-2',3'-dideoxyadenosine

Base Information

• Chemical Name: 2-chloro-2',3'-dideoxyadenosine
• CAS No.: 114849-58-0
• Molecular Formula: C₁₀H₁₂ClN₅O₂
• Molecular Weight: 269.691
• Mol file: 114849-58-0.mol

Synonyms:2-Chloro-2',3'-dideoxyadenosine;NSC 619531

Chemical Property of 2-chloro-2',3'-dideoxyadenosine

Chemical Property:

• Refractive Index: 1.5500 (estimate)
• Boiling Point: 471.4°Cat760mmHg
• Flash Point: 238.9°C
• PSA: 99.08000
• Density: 1.88g/cm³
• LogP: 1.31300
• Water Solubility.: 1.01g/L(25 oC)

Purity/Quality:

97% ^*data from raw suppliers

2-CHLORO-2',3'-DIDEOXYADENOSINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-2',3'-dideoxyadenosine

There total 19 articles about 2-chloro-2',3'-dideoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-chloro-9-<2,3-dideoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-glycero-pentofuranosyl>-9H-purin-6-amine (156834-11-6) → 2-chloro-2',3'-dideoxyadenosine (114849-58-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 12h; Ambient temperature;

DOI:10.1002/hlca.19940770305

Reference yield: 65.0%

9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-chloro-9H-purin-6-ylamine (119530-62-0) → 2-chloro-2',3'-dideoxyadenosine (114849-58-0)

Guidance literature:

With silica gel; In benzene; for 60h; Ambient temperature;

DOI:10.1021/jm00125a031

Reference yield: 57.0%

2-chloro-9-<2,3-dideoxy-5-O-<(1,1-dimethylethyl)dimethylsilyl>-β-D-glycero-pentofuranosyl>-9H-purin-6-amine (157786-86-2) → 2-chloro-2',3'-dideoxyadenosine (114849-58-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1002/hlca.19940770305

upstream raw materials:

9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-chloro-9H-purin-6-ylamine

2-chloro-9-<2,3-dideoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-glycero-pentofuranosyl>-9H-purin-6-amine

2-chloro-9-<2,3-dideoxy-5-O-<(1,1-dimethylethyl)dimethylsilyl>-β-D-glycero-pentofuranosyl>-9H-purin-6-amine

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

Refernces

• 1、 -. "L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents". . . Retrieved 2008/06/13.
• 2、 Seela,Gabler. "Facile synthesis of 2'-deoxyisoguanosine and related 2',3'-dideoxyribonucleosides". . p. 622 - 630. Retrieved 2007/10/02.