9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-chloro-9H-purin-6-ylamine

Base Information

Chemical Name:9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-chloro-9H-purin-6-ylamine
CAS No.:119530-62-0
Molecular Formula:C₃₁H₃₀ClN₅O₄
Molecular Weight:572.063
Hs Code.:

Synonyms:9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-chloro-9H-purin-6-ylamine

Suppliers and Price of 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-chloro-9H-purin-6-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-chloro-9H-purin-6-ylamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-chloro-9H-purin-6-ylamine

There total 4 articles about 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-chloro-9H-purin-6-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119530-58-4
2-Chloro-5'-O-(4,4'-dimethoxytrityl)-2',3'-O-thiocarbonyladenosine

: 119530-62-0
9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-chloro-9H-purin-6-ylamine

: 119530-61-9
9-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2-chloro-9H-purin-6-ylamine

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 120 - 130 ℃; for 48h; Yield given. Yields of byproduct given;
DOI:10.1021/jm00125a031

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 119530-62-0
9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-chloro-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / pyridine / 24 h / Ambient temperature

2: 80 percent / acetonitrile / Ambient temperature

3: n-Bu₃SnH, AIBN / toluene / 48 h / 120 - 130 °C

With pyridine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; acetonitrile;
DOI:10.1021/jm00125a031

Reference yield:

: 146-77-0
2-Chloroadenosine

: 119530-62-0
9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-2-yl}-2-chloro-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / pyridine / 24 h / Ambient temperature

2: 80 percent / acetonitrile / Ambient temperature

3: n-Bu₃SnH, AIBN / toluene / 48 h / 120 - 130 °C

With pyridine; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; acetonitrile;
DOI:10.1021/jm00125a031