3,5-Di-t-butyl-4-hydroxybenzophenone

Base Information

• Chemical Name: 3,5-Di-t-butyl-4-hydroxybenzophenone
• CAS No.: 7175-89-5
• Molecular Formula: C21H26O2
• Molecular Weight: 310.436
• DSSTox Substance ID: DTXSID60365506
• Wikidata: Q82150237
• Mol file: 7175-89-5.mol

Synonyms:3,5-di-t-butyl-4-hydroxybenzophenone;7175-89-5;Oprea1_749646;SCHEMBL9135750;DTXSID60365506;IVJWTXOJMVZAEA-UHFFFAOYSA-N;Methanone, [3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]phenyl-;STK525984;AKOS005459492;(3,5-di-tert-butyl-4-hydroxyphenyl)(phenyl)methanone;(3,5-ditert-butyl-4-hydroxyphenyl)(phenyl)methanone;[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]phenylmethanone

Chemical Property of 3,5-Di-t-butyl-4-hydroxybenzophenone

Chemical Property:

• XLogP3: 6.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 310.193280068
• Heavy Atom Count: 23
• Complexity: 383

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C(=O)C2=CC=CC=C2

Technology Process of 3,5-Di-t-butyl-4-hydroxybenzophenone

There total 14 articles about 3,5-Di-t-butyl-4-hydroxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(3,5-di-tert-butyl-4-hydroxyphenyl)phenylcarbinol (20017-39-4) → 3,5-di-t-butyl-4-hydroxybenzophenone (7175-89-5)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; for 0.25h; Ambient temperature;

DOI:10.1021/jo01297a010

Reference yield: 93.0%

2,6-di-tert-butylphenol (128-39-2) + benzoyl chloride (98-88-4) → 3,5-di-t-butyl-4-hydroxybenzophenone (7175-89-5)

Guidance literature:

With aluminium trichloride;

Reference yield: 65.0%

2,6-di-tert-butylphenol (128-39-2) + benzoic acid (65-85-0,8013-63-6) → 3,5-di-t-butyl-4-hydroxybenzophenone (7175-89-5)

Guidance literature:

With trifluoroacetic anhydride; for 3h; Ambient temperature;

DOI:10.1021/jo00133a009

upstream raw materials:

(3,5-di-tert-butyl-4-hydroxyphenyl)phenylcarbinol

2,6-di-tert-butylphenol

benzoyl chloride

2,6-Di-tert-butyl-4-(1-phenyl-vinyl)-phenol

Downstream raw materials:

4-Benzoyl-2,6-di-tert-butyl-phenoxyl

TZI-41078

3,5-di-t-butyl-4-hydroxybenzophenone dimethylhydrazone

3,5-di-t-butyl-4-hydroxybenzophenone semicarbazone

Refernces

• 1、 Monastyrskaya,Lyutkin,Gorbunov,Klimov. "Synthesis and Electrochemical Characteristics of 1-(3,5-Di-tert-butyl-4-hydroxyphenyl)alkyl(aryl)ketones and Radicals Obtained Therefrom". . p. 1409 - 1416. Retrieved 2007/10/03.
• 2、 Sergovskaya, N. L.,Kornienko, N. I.,Shekhter, O. V.,Tsizin, Yu. S.. "INVESTIGATION OF COMPOUNDS WITH JUVENILE ACTIVITY. XV. SYNTHESIS OF 2,6-DI-TERT-BUTYL-4-ACYLPHENOLS". . p. 1910 - 1913. Retrieved 2007/10/02.