Methyl 3-(piperidin-4-yl)propanoate

Base Information

• Chemical Name: Methyl 3-(piperidin-4-yl)propanoate
• CAS No.: 71879-50-0
• Molecular Formula: C9H17NO2
• Molecular Weight: 171.239
• DSSTox Substance ID: DTXSID30437441
• Wikidata: Q82252930
• Mol file: 71879-50-0.mol

Synonyms:methyl 3-(piperidin-4-yl)propanoate;71879-50-0;methyl 3-piperidin-4-ylpropanoate;3-piperidin-4-yl-propionic acid methyl ester;4-Piperidinepropanoic acid, methyl ester;Methyl 3-(4-piperidyl)propanoate;SCHEMBL380886;DTXSID30437441;FGTFCEJPMHOBDS-UHFFFAOYSA-N;Methyl 3-[piperid-4-yl]propionate;methyl3-(piperidin-4-yl)propanoate;Methyl 3-(4-piperidinyl)-propionate;MFCD09055353;AKOS011497996;SB38439;AM101187;PS-18062;CS-0029932;EN300-147341;P20545;A1-07511

Chemical Property of Methyl 3-(piperidin-4-yl)propanoate

Chemical Property:

• Boiling Point: 232.8±13.0 °C(Predicted)
• PKA: 10.52±0.10(Predicted)
• PSA: 38.33000
• Density: 0.969±0.06 g/cm3(Predicted)
• LogP: 1.26800
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 171.125928785
• Heavy Atom Count: 12
• Complexity: 142

Purity/Quality:

97% ^*data from raw suppliers

3-Piperidin-4-yl-propionic acid methyl ester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)CCC1CCNCC1

Technology Process of Methyl 3-(piperidin-4-yl)propanoate

There total 5 articles about Methyl 3-(piperidin-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(E)-methyl 3-(pyridine-4-yl)prop-2-enoate (81124-49-4,7340-34-3) → methyl 3-(4-piperidinyl)-propionate (71879-50-0)

Guidance literature:

With hydrogen; acetic acid; platinum(IV) oxide; at 20 ℃; for 30h;

DOI:10.1021/jm9811209

Reference yield:

3-(4-piperidyl)propionic acid (1822-32-8) → methyl 3-(4-piperidinyl)-propionate (71879-50-0)

Guidance literature:

With thionyl chloride; In methanol;

Reference yield:

pyridine-4-carbaldehyde (872-85-5) → methyl 3-(4-piperidinyl)-propionate (71879-50-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 72.8 percent / CH₂Cl₂ / 3 h / Heating

2: 61 percent / glac. AcOH; H₂ / PtO₂ / 30 h / 20 °C

With hydrogen; acetic acid; platinum(IV) oxide; In dichloromethane; 1: Condensation / 2: Catalytic hydrogenation;

DOI:10.1021/jm9811209

upstream raw materials:

(E)-methyl 3-(pyridine-4-yl)prop-2-enoate

pyridine-4-carbaldehyde

3-(4-piperidyl)propionic acid

methanol

Downstream raw materials:

Methyl N-[4-nitrophenyloxycarbonyl]-3-(4-piperidinyl)-propionate

tert-Butyl 4-[4-(3-methoxy-3-oxopropyl)piperidin-1-yl]benzoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 71879-50-0 methyl 3-piperidin-4-ylpropanoate(SALTDATA: HCl)

Send

Send

Metric Ton KG G Pound L ML

Send

Send