4-Chloro-alpha-(4-methoxyphenyl)benzenepropanenitrile

Base Information

Chemical Name:4-Chloro-alpha-(4-methoxyphenyl)benzenepropanenitrile
CAS No.:72035-47-3
Molecular Formula:C16H14ClNO
Molecular Weight:271.746
Hs Code.:
DSSTox Substance ID:DTXSID401233311

Synonyms:4-Chloro-alpha-(4-methoxyphenyl)benzenepropanenitrile;DTXSID401233311;72035-47-3

Suppliers and Price of 4-Chloro-alpha-(4-methoxyphenyl)benzenepropanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Chloro-alpha-(4-methoxyphenyl)benzenepropanenitrile

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:271.0763918
Heavy Atom Count:19
Complexity:308

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(CC2=CC=C(C=C2)Cl)C#N

Technology Process of 4-Chloro-alpha-(4-methoxyphenyl)benzenepropanenitrile

There total 3 articles about 4-Chloro-alpha-(4-methoxyphenyl)benzenepropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 72030-12-7
(Z)-3-(4-chlorophenyl)-2-(4-methoxyphenyl)acrylonitrile

: 72035-47-3
3-(4-Chloro-phenyl)-2-(4-methoxy-phenyl)-propionitrile

Guidance literature:: With sodium tetrahydroborate; In N,N-dimethyl-formamide; Ambient temperature; overnight;
DOI:10.1021/jo01289a038

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 72035-47-3
3-(4-Chloro-phenyl)-2-(4-methoxy-phenyl)-propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 40 percent aq. NaOH

2: 90 percent / NaBH₄ / dimethylformamide / Ambient temperature; overnight

With sodium hydroxide; sodium tetrahydroborate; In N,N-dimethyl-formamide;
DOI:10.1021/jo01289a038

Reference yield:

: 104-47-2
p-methoxybenzylnitrile

: 72035-47-3
3-(4-Chloro-phenyl)-2-(4-methoxy-phenyl)-propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 40 percent aq. NaOH

2: 90 percent / NaBH₄ / dimethylformamide / Ambient temperature; overnight

With sodium hydroxide; sodium tetrahydroborate; In N,N-dimethyl-formamide;
DOI:10.1021/jo01289a038