Methyl 4-aMino-1-Methyl-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: Methyl 4-aMino-1-Methyl-1H-pyrrole-2-carboxylate
• CAS No.: 72083-62-6
• Molecular Formula: C7H10N2O2
• Molecular Weight: 154.169
• Hs Code.: 2933990090
• Mol file: 72083-62-6.mol

Synonyms:1H-Pyrrole-3-carboxylic acid,1-methyl-,methyl ester;methyl 1-methyl-3-pyrrolecarboxylate;methyl 4-amino-1-methyl-pyrrole-2-carboxylate;methyl 1-methyl-1H-pyrrole-3-carboxylate;3-amino-1-methyl-5-methyloxycarbonylpyrrole;methyl 1-methyl-4-aminopyrrole-2-carboxylate;N-methyl-4-aminopyrrole-2-carboxylic acid methyl ester;methyl N-methyl-4-amino-2-pyrrolecarboxylate;methylpyrrole-3-carboxylic acid methyl ester;

Chemical Property of Methyl 4-aMino-1-Methyl-1H-pyrrole-2-carboxylate

Chemical Property:

• PSA: 57.25000
• LogP: 0.97510

Purity/Quality:

NLT 98% ^*data from raw suppliers

Methyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-aMino-1-Methyl-1H-pyrrole-2-carboxylate

There total 11 articles about Methyl 4-aMino-1-Methyl-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-4-nitropyrrole-2-carboxylic acid methyl ester (13138-76-6) → methyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate (72083-62-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 3h; Ambient temperature;

DOI:10.1021/ja00095a001

Reference yield: 98.0%

methyl 4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrole-2-carboxylate (126092-96-4) → methyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate (72083-62-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 0 - 20 ℃; for 20h;

DOI:10.1016/j.bmcl.2017.03.052

Reference yield:

1-methyl-4-nitro-2-trichloroacetylpyrrole (120122-47-6) → methyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate (72083-62-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 80 °C

2: H₂ / Pd/C / methanol / 2 h / 2585.81 Torr

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1039/b303650m

upstream raw materials:

1-methyl-4-nitropyrrole-2-carboxylic acid methyl ester

methyl 4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrole-2-carboxylate

1-methyl-4-nitro-2-trichloroacetylpyrrole

1-Methyl-2-pyrrolecarboxylic acid

Downstream raw materials:

methyl 4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrole-2-carboxylate

methyl 4-<<<4-<<(tert-butyloxy)carbonyl>amino>-1-methyl-pyrrol-2-yl>carbonyl>amino>-1-methyl-pyrrole-2-carboxylate

methyl 1-methyl-4-<4-bis(2-chloroethyl)aminophenylamido>pyrrole-2-carboxylate

4-(3-benzyl-ureido)-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester