a-hydroxy-2-Pyrrolidineacetic acid

Base Information

Chemical Name:a-hydroxy-2-Pyrrolidineacetic acid
CAS No.:72351-44-1
Molecular Formula:C6H11NO3
Molecular Weight:145.158
Hs Code.:
Mol file:72351-44-1.mol

Synonyms:(RS)-2-hydroxy-2-[(RS)-2-pyrrolidinyl]acetic acid;2-hydroxy-2-(pyrrolidin-2-yl)acetic acid;(R,S)-2-Hydroxy-2-(L-pyrrolidin-2-yl)acetic acid;

Suppliers and Price of a-hydroxy-2-Pyrrolidineacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AccelPharmtech
a-hydroxy-2-Pyrrolidineaceticacid 97.00%
5G
$ 3230.00

AccelPharmtech
a-hydroxy-2-Pyrrolidineaceticacid 97.00%
1G
$ 1890.00

Total 1 raw suppliers

Chemical Property of a-hydroxy-2-Pyrrolidineacetic acid

Chemical Property:

PSA：69.56000
LogP:-0.48730

Purity/Quality:: a-hydroxy-2-Pyrrolidineaceticacid 97.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of a-hydroxy-2-Pyrrolidineacetic acid

There total 6 articles about a-hydroxy-2-Pyrrolidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.9%

: 72351-44-1
2-Hydroxy-2-(L-pyrrolidin-2-yl)acetic acid

Guidance literature:

Reference yield: 35.0%

: 2-hydroxy-2-(pyrrolidin-2-yl)acetic acid hydrochloride

: 72351-44-1
2-Hydroxy-2-(L-pyrrolidin-2-yl)acetic acid

Guidance literature:

Reference yield:

: 182967-41-5
(S)-2-(3,5-Dimethyl-pyrazole-1-carbonyl)-pyrrolidine-1-carboxylic acid benzyl ester

: 72351-44-1
2-Hydroxy-2-(L-pyrrolidin-2-yl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄ / tetrahydrofuran / 1.5 h / -20 - -15 °C

2: 1.) Na₂S₂O₅ / 1.) ethyl acetate, H₂O, overnight, 2.) EtOAc, H₂O, 0 deg C, 30 min; room temperature, 4 h

3: 1.) 12N HCl, 2.) Dowex₅₀W-X₄, H⁺ / 1.) dioxane, reflux, 6 h, 2.) H₂O

With hydrogenchloride; sodium metabisulfite; lithium aluminium tetrahydride; Dowex₅₀W-X₄; hydrogen cation; In tetrahydrofuran;
DOI:10.7164/antibiotics.49.900