2-Pyrrolidineacetic acid, a-hydroxy-1-[(phenylmethoxy)carbonyl]-

Base Information

Chemical Name:2-Pyrrolidineacetic acid, a-hydroxy-1-[(phenylmethoxy)carbonyl]-
CAS No.:72351-45-2
Molecular Formula:C14H17NO5
Molecular Weight:279.293
Hs Code.:

Synonyms:

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Chemical Property of 2-Pyrrolidineacetic acid, a-hydroxy-1-[(phenylmethoxy)carbonyl]-

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Technology Process of 2-Pyrrolidineacetic acid, a-hydroxy-1-[(phenylmethoxy)carbonyl]-

There total 8 articles about 2-Pyrrolidineacetic acid, a-hydroxy-1-[(phenylmethoxy)carbonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.3%

: 501-53-1,94274-21-2
benzyl chloroformate

: 72351-44-1
2-Hydroxy-2-(L-pyrrolidin-2-yl)acetic acid

: 72351-45-2
2-Hydroxy-2-(N-benzyloxycarbonylpyrrolidin-2-yl)-acetic acid

Guidance literature:: With sodium hydroxide; In water;

Reference yield:

: 105706-84-1
(S)-2-formyl-1-pyrrolidinecarboxylic acid,phenylmethyl ester

: 72351-45-2
2-Hydroxy-2-(N-benzyloxycarbonylpyrrolidin-2-yl)-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Na₂S₂O₅ / 1.) ethyl acetate, H₂O, overnight, 2.) EtOAc, H₂O, 0 deg C, 30 min; room temperature, 4 h

2: 1.) 12N HCl, 2.) Dowex₅₀W-X₄, H⁺ / 1.) dioxane, reflux, 6 h, 2.) H₂O

3: Et₃N / H₂O; dioxane / 3 h / Ambient temperature

With hydrogenchloride; sodium metabisulfite; Dowex₅₀W-X₄; hydrogen cation; triethylamine; In 1,4-dioxane; water;
DOI:10.7164/antibiotics.49.900

Reference yield:

: 182758-72-1
2-(Cyano-hydroxy-methyl)-pyrrolidine-1-carboxylic acid benzyl ester

: 72351-45-2
2-Hydroxy-2-(N-benzyloxycarbonylpyrrolidin-2-yl)-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 12N HCl, 2.) Dowex₅₀W-X₄, H⁺ / 1.) dioxane, reflux, 6 h, 2.) H₂O

2: Et₃N / H₂O; dioxane / 3 h / Ambient temperature

With hydrogenchloride; Dowex₅₀W-X₄; hydrogen cation; triethylamine; In 1,4-dioxane; water;
DOI:10.7164/antibiotics.49.900