1-(4-Ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid

Base Information

• Chemical Name: 1-(4-Ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid
• CAS No.: 72370-87-7
• Molecular Formula: C13H12F4O3
• Molecular Weight: 292.23
• DSSTox Substance ID: DTXSID70531174

Synonyms:72370-87-7;1-(4-Ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid;SCHEMBL9753539;DTXSID70531174;GIODGGUATRIZGS-UHFFFAOYSA-N;1-(4-ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane carboxylic acid

Chemical Property of 1-(4-Ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 292.07225689
• Heavy Atom Count: 20
• Complexity: 391

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=C(C=C1)C2(CC(C2(F)F)(F)F)C(=O)O

Technology Process of 1-(4-Ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid

There total 2 articles about 1-(4-Ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane carboxylic acid ethyl ester → 1-(4-ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid (72370-87-7)

Guidance literature:

With sodium hydroxide; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol; water;

Reference yield:

→ 1-(4-ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid (72370-87-7)

Guidance literature:

Reference yield:

3-Phenoxybenzyl alcohol (13826-35-2) + 1-(4-ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid (72370-87-7) → 3'-phenoxybenzyl 1-(4-ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane carboxylate (72370-88-8)

Guidance literature:

With pyridine; thionyl chloride; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; Petroleum ether; benzene;

Downstream raw materials:

1-(4-Ethoxy-phenyl)-2,2,3,3-tetrafluoro-cyclobutanecarbonyl chloride

S(+)-1-(4-ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane carboxylic acid

R(-)-1-(4-ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane carboxylic acid

(S)-1-(4-Ethoxy-phenyl)-2,2,3,3-tetrafluoro-cyclobutanecarboxylic acid (3aR,4R,6aR)-2,2-dimethyl-6-oxo-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

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