(1R)-1-(4-Ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid

Base Information

Chemical Name:(1R)-1-(4-Ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid
CAS No.:72370-89-9
Molecular Formula:C₁₃H₁₂F₄O₃
Molecular Weight:292.23
Hs Code.:
DSSTox Substance ID:DTXSID30531175
Wikidata:Q82402832

Synonyms:72370-89-9;(1R)-1-(4-Ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid;DTXSID30531175

Suppliers and Price of (1R)-1-(4-Ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (1R)-1-(4-Ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:292.07225689
Heavy Atom Count:20
Complexity:391

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=CC=C(C=C1)C2(CC(C2(F)F)(F)F)C(=O)O
Isomeric SMILES:CCOC1=CC=C(C=C1)[C@]2(CC(C2(F)F)(F)F)C(=O)O

Technology Process of (1R)-1-(4-Ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid

There total 5 articles about (1R)-1-(4-Ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91627-21-3
1-(4-Ethoxy-phenyl)-2,2,3,3-tetrafluoro-cyclobutanecarbonyl chloride

: 72370-89-9
R(-)-1-(4-ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 6.0 g / pyridine / tetrahydrofuran

2: 10percent aq. NaOH / methanol / Ambient temperature

With pyridine; sodium hydroxide; In tetrahydrofuran; methanol;

Reference yield:

: 72370-87-7
1-(4-ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane-1-carboxylic acid

: 72370-89-9
R(-)-1-(4-ethoxyphenyl)-2,2,3,3-tetrafluorocyclobutane carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / Heating

2: 6.0 g / pyridine / tetrahydrofuran

3: 10percent aq. NaOH / methanol / Ambient temperature

With pyridine; sodium hydroxide; thionyl chloride; In tetrahydrofuran; methanol;