N-Benzoyl-5'-O-[(4-methoxyphenyl)(diphenyl)methyl]cytidine

Base Information

• Chemical Name: N-Benzoyl-5'-O-[(4-methoxyphenyl)(diphenyl)methyl]cytidine
• CAS No.: 72409-15-5
• Molecular Formula: C36H33N3O7
• Molecular Weight: 619.674
• DSSTox Substance ID: DTXSID00562395
• Wikidata: Q82446530

Synonyms:72409-15-5;DTXSID00562395;N-Benzoyl-5'-O-[(4-methoxyphenyl)(diphenyl)methyl]cytidine

Chemical Property of N-Benzoyl-5'-O-[(4-methoxyphenyl)(diphenyl)methyl]cytidine

Chemical Property:

• XLogP3: 4.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 10
• Exact Mass: 619.23185040
• Heavy Atom Count: 46
• Complexity: 1070

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC4C(C(C(O4)N5C=CC(=NC5=O)NC(=O)C6=CC=CC=C6)O)O
• Isomeric SMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC[C@@H]4[C@H]([C@H]([C@@H](O4)N5C=CC(=NC5=O)NC(=O)C6=CC=CC=C6)O)O

Technology Process of N-Benzoyl-5'-O-[(4-methoxyphenyl)(diphenyl)methyl]cytidine

There total 5 articles about N-Benzoyl-5'-O-[(4-methoxyphenyl)(diphenyl)methyl]cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N4-benzoylcytidine (13089-48-0) + mono-4-methoxytrityl chloride (14470-28-1) → N4-benzoyl-5'-O-(4-monomethoxytrityl)cytidine (72409-15-5)

Guidance literature:

In pyridine; dimethyl sulfoxide; for 24h; Ambient temperature;

Reference yield:

CYTIDINE (65-46-3) → N4-benzoyl-5'-O-(4-monomethoxytrityl)cytidine (72409-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / dioxane; H₂O / 4 h / 90 °C

2: 82 percent / pyridine / 18 h / 20 °C

With pyridine; In 1,4-dioxane; water;

DOI:10.1055/s-2002-35221

Reference yield:

benzoic acid anhydride (93-97-0) → N4-benzoyl-5'-O-(4-monomethoxytrityl)cytidine (72409-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / dioxane; H₂O / 4 h / 90 °C

2: 82 percent / pyridine / 18 h / 20 °C

With pyridine; In 1,4-dioxane; water;

DOI:10.1055/s-2002-35221

upstream raw materials:

N₄-benzoylcytidine

mono-4-methoxytrityl chloride

benzoic acid anhydride

CYTIDINE

Downstream raw materials:

N⁴-benzoyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(4-monomethoxytrityl)cytidine

N⁴-Benzoyl-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-O-(4-methoxytrityl)cytidin

N⁴-benzoyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4-monomethoxytrityl)cytidine

N-[1-((R)-2-Hydroxy-1-{(S)-1-hydroxymethyl-2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethoxy}-ethyl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide

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