10.3390/molecules17089590
The research focuses on the design and synthesis of a novel ganglioside ligand intended to target Influenza A viruses. The purpose of this study was to create a compound that could be recognized by these viruses, potentially aiding in the development of antiviral strategies. The researchers aimed to synthesize a ganglioside bearing both Neu5Acα2-3Gal and Neu5Acα2-6Gal sequences, which are known to be essential for viral transmission. In the process, a variety of chemicals were used, including sialyl donors, galactosyl acceptors, N-iodosuccinimide (NIS), triflic acid (TfOH), zinc-copper couple (Zn-Cu), acetic anhydride (Ac2O), palladium on carbon (Pd(OH)2/C), benzoic anhydride (Bz2O), and diammonium cerium(IV) nitrate (CAN), among others. These chemicals were employed in a series of complex reactions to construct the desired ganglioside structure, involving glycosylation, protection and deprotection of functional groups, and purification steps.
10.3184/174751912X13460810792101
The research focuses on developing a green and efficient method for the acylation of amines and phenols using hydrotalcite as a catalyst in water at room temperature. The study aimed to overcome the disadvantages of traditional methods, such as the use of toxic solvents and complicated reaction conditions, by following the principles of green chemistry. The experiments involved the reaction of various amines and phenols with carboxylic acid anhydrides and chlorides, using different amounts of water and catalyst to optimize the reaction conditions. The reactants included 4-methoxyaniline, 4-nitrobenzoyl chloride, and other substituted amines and phenols, along with acetylating agents like acetic anhydride and benzoic anhydride. The analyses used to characterize the products included Fourier-transform infrared spectroscopy (FT-IR), proton (1H) and carbon (13C) nuclear magnetic resonance (NMR) spectroscopy. The results showed that the method was effective, yielding moderate to high yields of amides and esters with good purity, and the catalyst could be reused without significant loss of activity.
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