Methyl 2-phenyl-1H-benzimidazole-4-carboxylate

Base Information

Chemical Name:Methyl 2-phenyl-1H-benzimidazole-4-carboxylate
CAS No.:72470-43-0
Molecular Formula:C15H12N2O2
Molecular Weight:252.272
Hs Code.:
DSSTox Substance ID:DTXSID40593103
Nikkaji Number:J2.480.244B
Wikidata:Q82487513

Synonyms:Methyl 2-phenyl-1H-benzimidazole-4-carboxylate;72470-43-0;SCHEMBL697780;DTXSID40593103;HGDDYLPGUIZRHE-UHFFFAOYSA-N;AKOS017557987;methyl 2-phenyl-1H-benzo[d]imidazole-7-carboxylate

Suppliers and Price of Methyl 2-phenyl-1H-benzimidazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 2-phenyl-1H-benzimidazole-4-carboxylate

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:252.089877630
Heavy Atom Count:19
Complexity:328

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=C2C(=CC=C1)NC(=N2)C3=CC=CC=C3

Technology Process of Methyl 2-phenyl-1H-benzimidazole-4-carboxylate

There total 10 articles about Methyl 2-phenyl-1H-benzimidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 100-52-7
benzaldehyde

: 107582-20-7
2,3-diaminobenzoic acid methyl ester

: 72470-43-0
2-phenylbenzimidazole-4-carboxylic acid methyl ester

Guidance literature:: In nitrobenzene; at 155 - 160 ℃; for 3h;

Reference yield:

: 181135-43-3
methyl 2-amino-3-N-benzoylaminobenzoate

: 72470-43-0
2-phenylbenzimidazole-4-carboxylic acid methyl ester

Guidance literature:: In acetic acid; at 120 ℃;

Reference yield:

: 5337-09-7
2-bromo-3-nitro-benzoic acid methyl ester

: 72470-43-0
2-phenylbenzimidazole-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / CH₂Cl₂ / 47 h / 20 °C

2: 45 percent / carbon monoxide; 1,10-phenanthroline monohydrate / bis(dibenzylideneacetone)palladium / dimethylformamide / 139.5 h / 120 °C / 4560.31 Torr

With carbon monoxide; 1,10-phenanthroline hydrate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2007.05.010