3-Pyridinecarbonitrile, 1-amino-1,2-dihydro-6-methyl-2-oxo-4-(trifluoromethyl)-

Base Information

• Chemical Name: 3-Pyridinecarbonitrile, 1-amino-1,2-dihydro-6-methyl-2-oxo-4-(trifluoromethyl)-
• CAS No.: 72567-46-5
• Molecular Formula: C₈H₆F₃N₃O
• Molecular Weight: 217.15
• Hs Code.: 2933399990

Synonyms:1-Amino-6-methyl-2-oxo-4-trifluoromethyl-1,2-dihydro-pyridine-3-carbonitrile;1-Amino-3-cyano-4-trifluormethyl-6-methyl-pyridin-2-on;

Chemical Property of 3-Pyridinecarbonitrile, 1-amino-1,2-dihydro-6-methyl-2-oxo-4-(trifluoromethyl)-

Chemical Property:

• PSA: 71.81000
• LogP: 1.34218

Purity/Quality:

1-amino-6-methyl-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarbonitrile, 1-amino-1,2-dihydro-6-methyl-2-oxo-4-(trifluoromethyl)-

There total 2 articles about 3-Pyridinecarbonitrile, 1-amino-1,2-dihydro-6-methyl-2-oxo-4-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1,1,1-Trifluoro-2,4-pentanedione (367-57-7) + Cyanoacetohydrazide (140-87-4) → 1,2-dihydro-1-amino-4-trifluoromethyl-6-methyl-2-oxopyridine-3-carbonitrile (72567-46-5)

Guidance literature:

With diethylamine; In ethanol; for 2h; Heating;

Reference yield:

→ 1,2-dihydro-1-amino-4-trifluoromethyl-6-methyl-2-oxopyridine-3-carbonitrile (72567-46-5)

Guidance literature:

Pentandion 1;

Reference yield: 81.0%

2,6-difluorobenzoyl isocyanate (60731-73-9) + 1,2-dihydro-1-amino-4-trifluoromethyl-6-methyl-2-oxopyridine-3-carbonitrile (72567-46-5) → 1-(3-Cyano-6-methyl-2-oxo-4-trifluoromethyl-2H-pyridin-1-yl)-3-(2,6-difluoro-benzoyl)-urea (139392-01-1)

Guidance literature:

In dichloromethane; for 6h; Ambient temperature;

upstream raw materials:

1,1,1-Trifluoro-2,4-pentanedione

Cyanoacetohydrazide

Downstream raw materials:

1-(3-Cyano-6-methyl-2-oxo-4-trifluoromethyl-2H-pyridin-1-yl)-3-(2,6-dichloro-benzoyl)-urea

1-(3-Cyano-6-methyl-2-oxo-4-trifluoromethyl-2H-pyridin-1-yl)-3-(2,6-difluoro-benzoyl)-urea

1-(2-Chloro-6-fluoro-benzoyl)-3-(3-cyano-6-methyl-2-oxo-4-trifluoromethyl-2H-pyridin-1-yl)-urea

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