4-(4-Bromobutoxy)benzaldehyde

Base Information

• Chemical Name: 4-(4-Bromobutoxy)benzaldehyde
• CAS No.: 72621-19-3
• Molecular Formula: C11H13BrO2
• Molecular Weight: 257.127
• DSSTox Substance ID: DTXSID10518500
• Nikkaji Number: J1.722.612F
• Wikidata: Q82381210
• Mol file: 72621-19-3.mol

Synonyms:4-(4-bromobutoxy)benzaldehyde;72621-19-3;Benzaldehyde, 4-(4-bromobutoxy)-;4-(4-BROMO-BUTOXY)-BENZALDEHYDE;SCHEMBL2182381;DTXSID10518500;4-(4-bromo-n-butoxy)benzaldehyde;AKOS005133791;VS-10187;CS-0117612;G73523

Chemical Property of 4-(4-Bromobutoxy)benzaldehyde

Chemical Property:

• PSA: 26.30000
• LogP: 3.05300
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 256.00989
• Heavy Atom Count: 14
• Complexity: 153

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C=O)OCCCCBr

Technology Process of 4-(4-Bromobutoxy)benzaldehyde

There total 2 articles about 4-(4-Bromobutoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,4-dibromo-butane (110-52-1) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(4-bromobutoxy)benzaldehyde (72621-19-3)

Guidance literature:

With potassium carbonate; In acetone; for 48h; Reflux;

DOI:10.2174/1570180811666140915221955

Reference yield:

1,4-dibromo-butane (110-52-1) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 1,4-bis(4-formylphenoxy)butane (77355-00-1) + 4-(4-bromobutoxy)benzaldehyde (72621-19-3)

Guidance literature:

With sodium ethanolate; Yield given. Multistep reaction. Yields of byproduct given; 1.) ethanol, reflux, 4 h, 2.) reflux, 48 h;

DOI:10.1007/BF00765771

Reference yield: 99.0%

4-(4-bromobutoxy)benzaldehyde (72621-19-3) → 4-(4-azidobutoxy)benzaldehyde

Guidance literature:

With sodium azide; In dimethyl sulfoxide; at 20 ℃; for 3h;

DOI:10.2174/1573406414666180730111954

upstream raw materials:

1,4-dibromo-butane

4-hydroxy-benzaldehyde

Downstream raw materials:

4-(p-formylphenyloxy)butyltrimethylammonium bromide

4-(4-dimethylamino-butoxy)-benzaldehyde

(cis/cis)-2-[4-(4-bromobutoxy)phenyl]-4,5-diphenyl-1,3-dioxolane

1,4-bis(2-(4-((dimethylamino)butoxyphenyl))-(E)-1-ethenyl)benzene

Refernces

• 1、 Caruso, Enrico,Malacarne, Miryam C.,Marras, Emanuela,Papa, Ester,Bertato, Linda,Banfi, Stefano,Gariboldi, Marzia B.. "New BODIPYs for photodynamic therapy (PDT): Synthesis and activity on human cancer cell lines". . . Retrieved 2020.
• 2、 Steinmark, Ida Emilie,James, Arjuna L.,Chung, Pei-Hua,Morton, Penny E.,Parsons, Maddy,Dreiss, Cécile A.,Lorenz, Christian D.,Yahioglu, Gokhan,Suhling, Klaus. "Targeted fluorescence lifetime probes reveal responsive organelle viscosity and membrane fluidity". . . Retrieved 2019.
• 3、 Chen, Ji-Lei,Gao, Lian-Xun,Jiang, Feng-Lei,Liu, Yi,Wang, Jiang-Lin,Zhang, Lu,Zhou, Te. "A bright, red-emitting water-soluble BODIPY fluorophore as an alternative to the commercial Mito Tracker Red for high-resolution mitochondrial imaging". supporting information. p. 8639 - 8645. Retrieved 2021/11/04.
• 4、 Sang, Zhipei,Song, Qing,Cao, Zhongcheng,Deng, Yong,Tan, Zhenghuai,Zhang, Li. "Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer's disease". . . Retrieved 2021/03/04.